Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies

Gastrointestinal Tract Cancer Clinical Trial

Official title:

Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03433092
• Other study ID #: 2759067085
• Status: Completed
• Phase: N/A
• First received: February 7, 2018
• Last updated: February 15, 2018
• Start date: November 1, 2017
• Est. completion date: December 28, 2017

Study information

• Verified date: February 2018
• Source: West China Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Previous studies have suggested that serum carotenoids may be associated with risk of gastrointestinal tract cancer (GIT cancer), but the results were inconsistent. Thus, the investigators conducted a meta-analysis to evaluate the associations between serum carotenoids and risk of GIT cancer.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40641
• Est. completion date: December 28, 2017
• Est. primary completion date: November 20, 2017
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• The study had both case and control groups

• Serum carotenoids levels, relative risk (RR) or OR and corresponding 95% CI were reported

• Patients in case group were diagnosed with GIT cancer

Exclusion Criteria:

·Animal studies

Related Conditions & MeSH terms

• Gastrointestinal Neoplasms
• Gastrointestinal Tract Cancer

Intervention

Other:
• serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Locations

Country	Name	City	State
China	West China Hospital, Sichuan University	Chengdu	Sichuan

Sponsors (2)

Lead Sponsor	Collaborator
Yong Zhou	Sichuan Provincial Science and Technology Support Project (2016SZ0047)

Country where clinical trial is conducted

China, 

References & Publications (1)

Huang J, Lu MS, Fang YJ, Xu M, Huang WQ, Pan ZZ, Chen YM, Zhang CX. Serum carotenoids and colorectal cancer risk: A case-control study in Guangdong, China. Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700267. Epub 2017 Jul 31. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gastrointestinal Tract Cancer Incident Measure	The gastrointestinal tract cancer incident would be recorded during the follow-up years.	Through study completion, an average of 5 years.