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Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Tumors Clinical Trial

Official title:
A Trial of Dovitinib in Combination With Imatinib in Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumors After Failure to Imatinib and Sunitinib

Clinical Trial Summary

The objective of this study is to determine the recommended dose of combination of dovitinib and imatinib in phase I study.

Clinical Trial Description

combination of dovitinib and imatinib could lead to additive or synergistic effect in patients who had failure of standard TKI therapies including imatinib, sunitinib, and/or regorafenib. In this phase I-II study of dovitinib plus imatinib, we aim to determine a recommended dose of dovitinib plus imatinib and to evaluate the safety and activity of the combination at the recommended dose as a 3rd or more line of treatment in metastatic or unresectable GIST. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02268435
Study type Interventional
Source Asan Medical Center
Contact
Status Withdrawn
Phase Phase 1
Start date March 2015
Completion date November 2016
View Details
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