Ph II Study of Perifosine Plus Gleevec for Patients With GIST

Status Completed

Clinical Trial Summary

This is a Phase II trial designed to determine the efficacy and safety of perifosine plus imatinib mesylate in patients with advanced GIST who develop progressive disease or recurrence while receiving imatinib mesylate.

Clinical Trial Description

This is a Phase II study of perifosine in combination with imatinib mesylate in patients with advanced GIST. Each cycle lasts 28 days. There will be two treatment arms. On both arms, patients will continue the dose of imatinib mesylate taken during the period of disease progression. Patients will be randomized to one either a weekly or a daily perifosine treatment regimen at the time of registration. ;

Study Design

Related Conditions & MeSH terms

Gastrointestinal Stromal Tumors

Clinical Trial Details

NCT number	NCT00455559
Study type	Interventional
Source	AEterna Zentaris
Contact
Status	Completed
Phase	Phase 2
Start date	August 2006
Completion date	October 2011

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