Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Transit

Gastrointestinal Motility Clinical Trial

Official title: Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Transit

Status Recruiting

Clinical Trial Summary

This clinical trial aims to characterize a novel method of imaging the gastrointestinal tract in healthy subjects. The method is using laser-light and soundwaves and it is performed in a similar manner as conventional ultrasound. It is radiation-free and non-invasive.

Participants will ingest food mixed with the clinically-registered dye Indocyanine green. Researchers will measure the signal of the dye over different segments of the gastrointestinal tract, visualizing gastrointestinal transit.

Clinical Trial Description

This clinical trial aims to assess gastrointestinal transit by using contrast-enhanced multispectral optoacoustic tomography (MSOT). MSOT is able to visualize not only endogenous chromophores like hemoglobin but also exogenous chromophores such as Indocyanine green (ICG). Healthy subjects will ingest three different standardized meals, all of which are mixed with ICG. By measuring the signal intensity of ICG during gastrointestinal transit, gut motility can be assessed non-invasive and radiation free.

The goal is to compare transit times for different standardized meals, which are liquid, mushy, and solid. ;

Related Conditions & MeSH terms

• Gastrointestinal Motility

• NCT number: NCT05933096
• Study type: Interventional
• Source: University of Erlangen-Nürnberg Medical School
• Contact: Emmanuel Nedoschill, MD
• Phone: +49 9131 85 41151
• Email: emmanuel.nedoschill@uk-erlangen.de
• Status: Recruiting
• Phase: N/A
• Start date: November 17, 2023
• Completion date: December 24, 2024