Gut Microbiome in Colorectal Cancer

Status Completed

Clinical Trial Summary

This is a pilot feasibility study designed to investigate the alterations in the gut microbiome that occur during the course of treatment for colorectal cancer

Clinical Trial Description

This is a pilot feasibility study designed to investigate the alterations in the gut microbiome that occur during the course of treatment for colorectal cancer (CRC). Three patient cohorts will be followed. Cohort A: patients treated with oral fluoropyrimidine CAP as part of standard of care (SOC) chemotherapy. Cohort B: patients treated with TAS-102 including those receiving it in combination with Y-90 radioembolization as part of a clinical trial. Cohort C: patients receiving CAP plus immunotherapy (pembrolizumab) and bevacizumab as part of a clinical trial. Investigators will replace participants as needed to ensure a minimum of 10 evaluable participants per cohort (or minimum total of 30 evaluable patients). Evaluable participants are defined as patients with two analyzable stool samples including a baseline sample and at least one on-treatment sample to be used in endpoint analysis ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04054908
Study type	Observational
Source	University of California, San Francisco
Contact
Status	Completed
Phase
Start date	April 13, 2018
Completion date	June 30, 2022

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See also
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Gut Microbiome in Colorectal Cancer — GO

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms