Clinical Trials Logo
  1. Home
  2. Gastrointestinal Diseases
  3. NCT02865564

Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics

Gastrointestinal Diseases Clinical Trial

Official title:
Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics on Emergence of Functional Gastrointestinal Disorders, Body Composition, Mineral Bone Density and Fecal Microbiota in Infancy

Clinical Trial Summary

The aim of the study is to elucidate the relationship between postnatal antibiotic administration on development of gut microbiota and possible protective influence of simultaneously administration of probiotic during antibiotic therapy on development of gut microbiota, functional gastrointestinal disorders of infancy, weight gain and body composition.

Clinical Trial Description

The study is double-blind, placebo-controlled randomised trial and is composed from two parts. First part of the study aims to examine any difference in gut microbiota after postnatal antibiotic administration between the neonates who received probiotic Lactobacillus reuteri DSM 17938 or placebo and to compare the gut microbiota of patients to microbiota of healthy newborns. Second part of the study aims to determine whether probiotic L. reuteri DSM 17938 supplementation to antibiotic therapy has any beneficial influence on incidence of functional gastrointestinal disorders of infancy and body composition and bone density 6 weeks and one year after inclusion in the study. Additionally the associations of the clinical parameters with the composition and developmental characteristics of fecal microbiota during antibiotic treatment in children will be evaluated; relevant clinical data such as mode of delivery, child's nutrition, health problems, growth and developmental attributes which could be found associated with fecal microbial community, will be tracked and statistically evaluated for the investigated population. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02865564
Study type Interventional
Source University Medical Centre Ljubljana
Contact
Status Completed
Phase N/A
Start date November 2016
Completion date March 2020
View Details
See also
  Status Clinical Trial Phase
Terminated NCT02541357 - Preoperative Relaxation and Intensified Patient Surgery Education in Patients Undergoing Colorectal Surgery N/A
Active, not recruiting NCT02358122 - Determining the Potential of Wholegrain Wheat and Rye to Improve Gut HealTh N/A
Active, not recruiting NCT02442115 - Impact of Improving GI Symptoms on Autism Symptoms and Oxidative Stress
Enrolling by invitation NCT00943345 - Validation of New Tests for Gastrointestinal (GI) Permeability Phase 0
Completed NCT00612404 - Symptoms and Endoscopic Results in Consideration of Pretreatment N/A
Completed NCT01127711 - Cohort of Swedish Men N/A
Recruiting NCT05712525 - Gut Recovery In Patients Following Surgery
Recruiting NCT06094153 - Prebiotic Effects on Gut Microbiota, Gut Comfort and Immune Function N/A
Recruiting NCT05322486 - Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases
Completed NCT02486146 - GI Biorepository of Tissue and Bodily Fluids N/A
Completed NCT01816607 - Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness
Completed NCT00247715 - Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study) N/A
Completed NCT00035334 - Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis Phase 2/Phase 3
Recruiting NCT06286865 - Improving Quality of ICD-10 Coding Using AI: Protocol for a Crossover Randomized Controlled Trial N/A
Active, not recruiting NCT01037049 - Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks Phase 2
Completed NCT03725813 - Study Evaluating the Effect of Person-centred Care for Patients Admitted for Inpatient Care at an Internal Medicine Unit N/A
Recruiting NCT05640401 - Holographic Screens as a Replacement of Monitors During GI Endoscopies N/A
Completed NCT02651857 - Exploratory Study of Upper and Lower Endoscopic Fuse System N/A
Active, not recruiting NCT01984034 - Trial to Assess the Effectiveness of Educational Outreach in Prescription Guidelines N/A
Completed NCT01463319 - Warm Water and Unsedated Colonoscopy Phase 0