Gastrointestinal Diseases Clinical Trial
Official title:
Dubbelblind Crossover Study for Validation of New Tests for Gastrointestinal (GI) Permeability
Introduction: The primary function of the gastrointestinal (GI) wall is digestion and
absorption of nutrients that are important for growth and development. The second important
function of the GI wall is forming an effective barrier to prevent penetration of
potentially harmful components from the inside of the gut (lumen), via the GI wall, into the
body.
A compromised barrier function may play an important role in the development of a range of
inflammatory GI diseases such as coeliac disease, Inflammatory Bowel Disease (IBD), food
allergy, but also in the pathophysiology of postoperative complications. It is important and
clinically relevant to have reliable GI permeability tests, however the existing test leave
room for improvement.
Rationale/aim: Three new tests are developed to assess gastrointestinal permeability in both
normal controls with and without raised permeability, and in patients with coeliac disease.
In the current study these new permeability tests will be evaluated and compared with the
golden standard permeability test, the dual sugar test.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Diagnostic
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