Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding

Status Recruiting

Clinical Trial Summary

In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.

Clinical Trial Description

Oxaliplatin is used as the first-line chemotherapy for colorectal cancer. However, oxaliplatin-induced hepatotoxicity could lead to sinusoidal injury and portal hypertension in the long term. Variceal bleeding, as the most common complication of portal hypertension, threaten these patents' life. Endoscopic treatment and Transjugular Intrahepatic Portosystemic Shunt (TIPS) are both recommended management of gastroesophageal variceal bleeding. In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding. ;

Study Design

Related Conditions & MeSH terms

Gastroesophageal Varices Hemorrhage
Gastrointestinal Cancer
Gastrointestinal Neoplasms
Hemorrhage
Received Oxaliplatin-based Chemotherapy

Clinical Trial Details

NCT number	NCT05141617
Study type	Interventional
Source	Shanghai Zhongshan Hospital
Contact	Xiaoquan HUANG, M.D.
Phone	008618801733835
Email	huang.xiaoquan@zs-hospital.sh.cn
Status	Recruiting
Phase	N/A
Start date	November 3, 2021
Completion date	December 31, 2023

View Details

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