Gastrointestinal Bleeding Clinical Trial
Official title:
Role of Triphasic Computed Tomography Imaging in the Detection of Acute Non-variceal Gastrointestinal Bleeding
Gastrointestinal bleeding represents a serious clinical problem and a common cause of
hospitalisation with a mortality rate of 6-10% for upper Gastrointestinal bleeding and of 4%
for lower Gastrointestinal bleeding requires a multidisciplinary approach involving
gastroenterologists, endoscopists, surgeons and radiologists.
Gastrointestinal bleeding is self-limited in 80% of cases requiring only supportive measures.
However, the persistence of bleeding represents a diagnostic challenge to locate the site of
bleeding especially in severe bleeding and to determine, if possible its cause. This will
allow to select the most appropriate therapeutic approach in order to reduce the morbidity
and mortality, the length of hospitalisation and the transfusion requirements.
Current diagnostic algorithms vary widely from institution to institution and from clinician
to clinician. Imaging modalities remain the mainstay of the diagnostic approach. They include
endoscopy, video capsule, radionuclide imaging, catheter angiography and multidetector
computed tomography imaging.
In recent years, Multidetector computed tomography has emerged as a promising technology to
evaluate Gastrointestinal bleeding. The modality's ease of use and rapid results favour its
use in any emergent situation. In addition, today's high-speed, narrow collimation
multi-detector technology allows a large coverage area with minimal motion artifacts, with
the ability to capture both arterial and venous phase with ease. Multidetector computed
tomography is being increasingly used as this is a widely available, non-invasive and fast
diagnostic technique that allows for visualisation of the entire intestinal tract and its
lesions, the identification of vascularity and possible vascular abnormalities.
Status | Not yet recruiting |
Enrollment | 30 |
Est. completion date | December 1, 2018 |
Est. primary completion date | August 1, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - patients with unexplained non variceal gastrointestinal bleeding Exclusion Criteria: - patients with impaired renal functions or terminal liver failure. pregnancy. patients known to be sensitive to contrast media. cases diagnosed endoscopically as variceal bleeding. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Geffroy Y, Rodallec MH, Boulay-Coletta I, Jullès MC, Ridereau-Zins C, Zins M. Multidetector CT angiography in acute gastrointestinal bleeding: why, when, and how. Radiographics. 2011 May-Jun;31(3):E35-46. Review. Erratum in: Radiographics. 2011 Sep-Oct;31(5):1496. Radiographics. 2011 Nov-Dec;31(7):2114. Fullès, Marie-Christine [corrected to Jullès, Marie-Christine]. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Role of triphasic computed tomography imaging in detection of acute non variceal gastrointestinal tract bleeding | Number of 30 patients with acute gastrointestinal bleeding will undergo multislice computed tomography angiography with 16 multislice computed tomography scanner with dose 1-2ml/kg body weight contrast media and the study will be revised to detect the contrast extravasation which means active bleeding, and will detect the cause of bleeding such as tumor, aneurysm, arteriovenous malformation....and confirmation of these results will be done by angiographic intervention and embolization of the bleeding vessel | one year |
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