Liver Cirrhosis Clinical Trial
Official title:
Comparison of Efficacy and Safety of Gastric Variceal Ligation Versus Gastric Variceal Obturation for Secondary Prophylaxis of Gastric Varices
The investigators establish a randomized controlled clinical trial, comparing the efficacy
and prognosis of GVL and GVO in secondary prevention of GVs, especially in patients with
portosystemic shunting, and exploring the endoscopic treatment selection of different types
of GVs.
Outcome expectations: Compared with glue injection, endoscopic ligation for secondary
prevention of gastric varices is safe and effective, especially in patients with
portosystemic shunting.
Gastric varices (GVs) is a common complication of portal hypertension, with an incidence of
20%. Though the bleeding rate of GVs (25%) is lower than that of Esophageal varices (EVs),
the mortality rate is higher due to greater GVs rupture and less space for endoscopic
intervention. In addition, in 30% of patients with GVs, the possibility of treatment failure
exists.
Guidelines differ on endoscopic treatment for secondary prevention of GVs.Current studies
suggest that EVL, due to its low incidence of complications, is suitable for GOV1, while it
is still controversial for the treatment of gastric varices. Compared with glue, the
advantage of ligation is that it can avoid serious complications caused by glue injection,
such as ectopic embolization, large ulcer and sepsis. As there are few studies comparing GVL
and GVO in secondary prevention of gastric varices, the treatment methods are different, and
the treatment effect is controversial. In addition, the choice of treatment for different
types of GVs needs further study.
The investigators establish a randomized controlled clinical trial, comparing the efficacy
and prognosis of GVL and GVO in secondary prevention of GVs, especially in patients with
portosystemic shunting, and exploring the endoscopic treatment selection of different types
of GVs.
Outcome expectations: Compared with glue injection, endoscopic ligation for secondary
prevention of gastric varices is safe and effective, especially in patients with
portosystemic shunting.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04533932 -
Endosonographic Shear Wave Elastography for Liver Stiffness
|
||
| Not yet recruiting |
NCT06031740 -
A Comparison of Flexible Endoscopic Polidocanol Liquid and Foam Sclerotherapy in Cirrhotic Patients With Bleeding From Internal Hemorrhoids
|
N/A | |
| Not yet recruiting |
NCT06026267 -
Efficacy of Conventional Dose Protocol vs Low Dose Protocol Albumin Use in Patients With Cirrhosis and High Risk Spontaneous Bacterial Peritonitis
|
N/A | |
| Not yet recruiting |
NCT06076330 -
Efficacy of 5% Albumin v/s Plasmalyte in Combination With 20% Albumin for Fluid Resuscitation in Cirrhosis With Sepsis Induced Hypotension
|
N/A | |
| Enrolling by invitation |
NCT05055713 -
A Randomized Controlled Study on the Treatment of Cirrhosis Combined With Hypersplenism
|
N/A | |
| Recruiting |
NCT04578301 -
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
|
||
| Not yet recruiting |
NCT05515861 -
Evaluation of EUS in Preventing Rebleeding After Endoscopic Cyanoacrylate Injection for Gastric Varices
|
N/A | |
| Not yet recruiting |
NCT05120557 -
Point-of-care Ultrasound Screening and Assessment of Chronic Liver Diseases and NASH
|
N/A | |
| Not yet recruiting |
NCT02710227 -
Sleep Timing and Circadian Preferences in A Sample of Egyptian Patients With Hepatic Cirrhosis
|
N/A | |
| Not yet recruiting |
NCT03623360 -
Functional MRI to Determine Severity of Cirrhosis
|
||
| Completed |
NCT02917408 -
Retrospective Study About Primary Biliary Cholangitis During January 2001 to July 2016 at West China Hospital
|
||
| Active, not recruiting |
NCT02551250 -
Annual MRI Versus Biannual US for Surveillance of Hepatocellular Carcinoma in Liver Cirrhosis
|
||
| Recruiting |
NCT02239991 -
Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
|
N/A | |
| Enrolling by invitation |
NCT02256514 -
Open Label Trial of Immunotherapy for Advanced Liver Cancer
|
Phase 2 | |
| Terminated |
NCT02311985 -
Comparison of Three Transfusion Strategies for Central Venous Catheterization in Cirrhotics: A Randomized Clinical Trial
|
N/A | |
| Terminated |
NCT01937130 -
Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
|
Phase 2 | |
| Recruiting |
NCT01728727 -
Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01728688 -
Safety and Efficacy of Human Autologous Peripheral Blood Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01618890 -
Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding
|
Phase 3 | |
| Recruiting |
NCT01724697 -
Safety and Efficacy of Human Bone Marrow Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 |