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Study of the Effects of Pantoprazole on Levels of Prescribed Psychiatric Medications — PK-PPI  

Psychotic Disorders Clinical Trial

Official title:
A Pilot Study to Determine if Pantoprazole Modifies Steady-State Plasma Concentrations of Orally Administered Psychotropic Medications

Clinical Trial Summary

The purpose of this 9-day study is to determine if: 1. Pantoprazole modifies the steady-state plasma concentrations of orally administered psychotropic medications including valproic acid, lithium, and second-generation antipsychotics (i.e., aripiprazole, asenapine, clozapine, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone) 2. Serum gastrin levels change within a week of starting or stopping pantoprazole

Clinical Trial Description

Individuals with psychiatric diagnoses may be predisposed to gastroesophageal reflux disease because of the widespread use of alcohol, cigarettes, and certain psychotropic drugs in this population. Consequently, they are often prescribed proton pump inhibitors. To our knowledge, no studies have been conducted to determine the effects of proton pump inhibitors on plasma levels of psychotropic drugs. The present clinical study will assess the effects of pantoprazole on the pharmacokinetics of valproic acid, lithium, and second-generation antipsychotics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02213887
Study type Interventional
Source University of British Columbia
Contact
Status Withdrawn
Phase Phase 4
Start date September 2014
Completion date November 2, 2020
View Details
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