Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease

Status Recruiting

Clinical Trial Summary

This study is to evaluate the safety and efficacy of radiofrequency energy procedure for Gastro-esophageal reflux disease (GERD) based on changes of symptoms, medication esophagitis grade, esophageal acid exposure and lower esophageal sphincter pressure. Symptom assessment was performed at baseline and 3, 6, 12 months after treatment.

Clinical Trial Description

Gastroesophageal reflux disease (GERD) is a chronic disease characterized by symptoms of heartburn and acid regurgitation. Uncontrolled GERD can significantly impact quality of life. The use of proton pump inhibitors (PPI) remains the mainstay therapy. However, the efficacy of this intervention is often hampered by adherence, costs, and the risks of long-term PPI use. Anti-reflux surgery is an option for patients with refractory symptoms or in those in whom medical therapy is contraindicated or not desirable, but the incidence of dysphagia, abdominal distension associated wth the surgery is high. Radiofrequency ablation, minimally invasive, less complications, has become alternative treatments options. But the current research on radiofrequency treatment of the data is limited in China. Therefore, the investigators conduct this multi-center clinical trial. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03223116
Study type	Interventional
Source	Changhai Hospital
Contact	luowei Wang, MD
Phone	13901833088
Email	wangluoweimd@126.com
Status	Recruiting
Phase	N/A
Start date	July 1, 2015
Completion date	July 1, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02135107` - A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients	Phase 3
Completed	`NCT01432392` - Symptom Control and Impact on Daily Life in Patients With Gastroesophageal Reflux Disease	N/A
Recruiting	`NCT01249482` - Symptom Assessment for GERD Patients Receiving H. Pylori Eradication	N/A
Completed	`NCT01578642` - Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease	Phase 2
Completed	`NCT01200550` - The Study to Describe Symptom Control and Impact on Daily Life in Gastroesophageal Reflux Disease (GERD) Patients	N/A
Completed	`NCT00998244` - Study to Evaluate the Effect of a Very Low Carbohydrate Diet on Gastroesophageal Reflux Disease	N/A
Completed	`NCT00978016` - A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)	Phase 2
Unknown status	`NCT01128608` - The Effect of High PCO2 Solution on Esophageal Acid Sensation	N/A
Completed	`NCT00768443` - Symptoms and Management Strategies in Gastroesophageal Reflux Disease (GERD)	N/A
Completed	`NCT00768196` - Prevalence of EED and Quality of Life Evaluated by Gastroesophageal Reflux Disease (GERD)-Q in Korean GERD Patients	N/A
Recruiting	`NCT00498082` - Determinants of Efficacy of EsophyX Treatment in Gastro-Esophageal Reflux Disease	N/A
Completed	`NCT00886197` - Diagnostic Efficacy of Narrow Band Imaging in Patients With Gastroesophageal Reflux Disease	N/A
Completed	`NCT00378898` - Feasibility of Placing Bravo PH Capsule in Proximal Esophagus	N/A
Completed	`NCT00217347` - Evaluation of Efficiency of Esophageal Capsule Endoscopy in the Screening of Patients With Gastroesophageal Reflux Disease or Dyspepsia as Compared to Upper Endoscopy	N/A
Completed	`NCT00507377` - Foreshortened Esophagus and Its Surgical Therapy
Completed	`NCT00165022` - Development of a Novel Disease-Specific Quality of Life Questionnaire for Gastroesophageal Reflux Disease (GERD) Patients in Chinese Population	N/A
Completed	`NCT00625495` - Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)	Phase 4
Completed	`NCT00214552` - Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma.	Phase 3
Completed	`NCT00618150` - Patient Education in Gastroesophageal Reflux Disease	N/A
Completed	`NCT03299985` - Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease	N/A