Gastroesophageal Reflux Disease Clinical Trial
Official title:
Efficacy of Imipramine for Treatment of Patients With Esophageal
Esophageal hypersensitivity/Functional heartburn are common among non-erosive reflux disease
(NERD) patients who do not response to proton pump inhibitors. Whether tricyclic
antidepressant improves NERD patient's symptoms remains unknown
Aim of this randomized controlled trial study is to determine the efficacy of imipramine,
which could increase esophageal pain thresholds in healthy volunteers, in comparison with
placebo for treatment patients with esophageal hypersensitivity or functional heartburn
evaluated by improvement of specific-symptom score and quality of life
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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