Gastro Intestinal Bleeding Clinical Trial
Official title:
Influence of Factor XIII Activity on the Outcome of Gastrointestinal Bleedings
Verified date | July 2023 |
Source | Medical University of Graz |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of this retrospective study is to investigate the relationship between factor XIII activity and the outcome of gastrointestinal bleedings. Since factor XIII is of great importance in haemostasis and plays a key role in stabilizing the fibrin clot, it can be assumed that a deficiency of factor XIII leads to an unfavorable course of gastrointestinal bleedings. Our hypothesis is that early detection of such a deficiency can prevent a more severe course and that substitution of factor XIII contributes to faster cessation of bleeding, improves patient outcome and reduces the number of red cell concentrates required.
Status | Active, not recruiting |
Enrollment | 97 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 100 Years |
Eligibility | Inclusion Criteria: - Age over 18 years - Confirmed diagnosis of gastrointestinal bleeding - Assessment of factor XIII activity during the gastrointestinal bleeding episode Exclusion Criteria: - Age under 18 years - Diagnosis of hemophilia A or B or other congenital coagulation disorders |
Country | Name | City | State |
---|---|---|---|
Austria | Medical University of Graz | Graz | Styria |
Lead Sponsor | Collaborator |
---|---|
Medical University of Graz |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Red cell concentrates | Number of red cell concentrates transfused during the hospital stay caused by the gastrointestinal bleeding episode | 1 year | |
Secondary | Hospitalization | Length of the hospital stay caused by the gastrointestinal bleeding episode | 1 year | |
Secondary | Interventions | Number of endoscopic, radiological, and surgical interventions for bleeding treatment within the hospital stay caused by the gastrointestinal bleeding episode | 1 year | |
Secondary | Mortality | In hospital-mortality during the hospital stay caused by the gastrointestinal bleeding episode | 1 year |
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