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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT04289519
Other study ID # EFOGIC
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date September 30, 2020
Est. completion date April 30, 2021

Study information

Verified date February 2020
Source Assiut University
Contact Naglaa Hassan, Professor
Phone 01111872237
Email naglaa.ibrahim@med.au.edu.eg
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Gastritis defines any (histologically confirmed) inflammation of the gastric mucosa


Description:

Gastritis is a very common disease in children. The main presentation of children with gastritis is recurrent abdominal pain and dyspepsia or vomiting. Young children may have hematemesis or melena as presentation. Drug induced or food related gastritis presents usually with acute symptoms but Helicobacter pylori gastritis have mainly recurrent abdominal pain and dyspeptic symptoms. Other presentations include diarrhea, constipation, flatulence, bloating, fatigue, low energy level, weight loss, muscle loss, bad breath etc.

The main causes of gastritis are infections, inflammation and other disorders affect the gastric mucosa in pediatric patients. Helicobacter pylori infection is the most common cause of gastritis in children which is also responsible for the majority of duodenal ulcers.

Acute erosive gastritis is most commonly the result of metabolic stress or drug or corrosive injury.

Other major causes of gastritis include celiac disease, allergic disorders, and Crohn's disease .Medication as NSAIDs, uremia, ischemia, shock, radiation, sepsis, trauma, severe burns and surgery.

Endoscopic pictures in acute gastritis may be in the form of:

- Multiple round-shaped severe erosions with a diameter of several millimeters.

- Mucosal edema, hyperemia.

- Peptic ulcer While in chronic gastritis is variable. Affects the antrum in the beginning and advances to the proximal in time .


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 500
Est. completion date April 30, 2021
Est. primary completion date October 30, 2020
Accepts healthy volunteers
Gender All
Age group N/A to 18 Years
Eligibility Inclusion Criteria:

- All children diagnosed as gastritis by upper endoscopy and bio gastric biopsy

Exclusion Criteria:

- • All children underwent upper endoscopy during the study period not diagnosed as gastritis

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Assiut University

References & Publications (6)

Glickman JN, Antonioli DA. Gastritis. Gastrointest Endosc Clin N Am. 2001 Oct;11(4):717-40, vii. Review. — View Citation

Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, Macarthur C, Snyder J, Sherman PM; North American Society for Pediatric Gastroenterology and Nutrition. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr. 2000 Nov;31(5):490-7. — View Citation

Kayaçetin S, Güresçi S. What is gastritis? What is gastropathy? How is it classified? Turk J Gastroenterol. 2014 Jun;25(3):233-47. doi: 10.5152/tjg.2014.7906. Review. — View Citation

Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006 Jul;19(3):449-90. Review. — View Citation

Pasechnikov VD, Chukov SZ, Kotelevets SM, Mostovov AN, Mernova VP, Polyakova MB. Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. Scand J Gastroenterol. 2005 Mar;40(3):297-301. — View Citation

Tam YH, Chan KW, To KF, Cheung ST, Mou JW, Pang KK, Wong YS, Sihoe JD, Lee KH. Impact of pediatric Rome III criteria of functional dyspepsia on the diagnostic yield of upper endoscopy and predictors for a positive endoscopic finding. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):387-91. doi: 10.1097/MPG.0b013e31820e2026. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary causes of gastritis in children as shown by upper endoscopy infections
inflammation
Helicobacter pylori
Acute erosive gastritis
average 1 year
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