Clinical Trials Logo

Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT01697943
Other study ID # 2012-44-563
Secondary ID
Status Recruiting
Phase Phase 3
First received September 28, 2012
Last updated October 15, 2012
Start date May 2012
Est. completion date May 2017

Study information

Verified date October 2012
Source Fudan University
Contact Ya Nong Wang, MD,PhD
Phone +86-21 64175590
Email huahuang@fudan.edu.cn
Is FDA regulated No
Health authority China: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

The purpose of this study is to find out more about differences of the quality of life in patients undergoing Roux-En-Y pouch reconstruction and conventional Roux-En-Y reconstruction. To find a better reconstruction for patients who received total gastrectomy.


Description:

Total gastrectomy has been indicated mainly for advanced gastric cancer located from the upper to middle third of the stomach or multiple gastric cancers.The most common method of creating a way for food is called a "Roux-en-Y", in which one part of the intestines is connected with the end of the esophagus (the swallowing tube) in the abdomen, and another connection is made between the intestines ' lower down.

Patients with total gastrectomy suffer from poor food intake, anemia, and poor digestion because of loss of gastric reservoir or a lack of normal hormonal secretion for digestion. It often is associated with a limitation of postoperative quality of life (QOL). To improve postoperative nutritional status and QOL, surgeons have tried to establish ideal reconstruction after total gastrectomy and the optimum procedure for reconstruction has been discussed.

This study will compare the postoperative quality of life (QOL) of gastric pouch reconstruction with the usual reconstruction to see if the pouch makes patients feel better.


Recruitment information / eligibility

Status Recruiting
Enrollment 140
Est. completion date May 2017
Est. primary completion date May 2015
Accepts healthy volunteers No
Gender Both
Age group 20 Years to 75 Years
Eligibility Inclusion Criteria:

- • Pathologically confirmed gastric malignant tumor at fUSCC (biopsy may be performed at other institutions but slides must be confirmed at SHCA, as is routine care at our institution) , and the patients be assessed must be carried out total gastrectomy by three specialists.

- Patients 20-75 years old

- Normal organ function, able to tolerate surgery, no clear contraindication for surgery

- No evidence of metastases of adjacent organs

- be able to provide follow-up over 2 years

- No specific treatment for gastric cancer before surgery

- In line with the Declaration of Helsinki and the requirements of the hospital ethics committee.

- The subjects were able to understand and comply with the trial protocol, and signed informed consent.

Exclusion Criteria:

- • Synchronous or metachronous (less than five years) and with other malignancies.

- Cirrhosis and portal hypertension

- Associated with blood diseases

- Serious heart/ lung and kidney dysfunction or with metabolic diseases such as diabetes, hyperthyroidism.

- Suffering from a serious neurological diseases or psychological diseases affecting the life

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Procedure:
Roux-En-Y Pouch Reconstruction or Conventional Roux-En-Y Reconstruction


Locations

Country Name City State
China Fudan University Shanghai Cancer Center Shanghai Shanghai

Sponsors (1)

Lead Sponsor Collaborator
Fudan University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change in QOL (Quality of Life) From preoperative following total gastrectomy, as measured with the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-STO22 questionnaires 5years No
Secondary Nutritional status of patients 5 years No
See also
  Status Clinical Trial Phase
Completed NCT02161029 - Flexible Endoscopy Biopsies for Submucous Tumors With a New Drill Instrument N/A
Completed NCT01510730 - Helicobacter Pylori Eradication After Endoscopic Resection of Gastric Tumors Phase 3
Not yet recruiting NCT01832246 - Endoscopic Ultrasonographic Staging and Conventional Endoscopic Staging for Depth of Invasion for Early Gastric Cancer N/A
Recruiting NCT01698190 - Comparing the Efficacy of Endoscopic FNA vs FNB in Diagnosing Solid Gastrointestinal Lesions N/A
Terminated NCT04510285 - A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resection Phase 2
Not yet recruiting NCT01819961 - Parenteral Fish Oil in Major Laparoscopic Abdominal Surgery Phase 4
Completed NCT01579071 - Efficacy and Safety of CO2 vs Room Air Insufflation During ESD for Gastric Tumor Phase 4