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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05107674
Other study ID # NX-1607-101
Secondary ID
Status Recruiting
Phase Phase 1
First received
Last updated
Start date September 29, 2021
Est. completion date February 28, 2026

Study information

Verified date June 2024
Source Nurix Therapeutics, Inc.
Contact Nurix Therapeutics Patient Outreach
Phone 4152307815
Email nx1607101@nurixtx.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-1607 in patients with advanced malignancies.


Description:

Phase 1a will consist of 2 study arms: Monotherapy and Paclitaxel combo. Phase 1a dose escalation will evaluate the safety and tolerability of NX-1607 in adult patients with advanced solid tumors for which standard therapy with proven clinical benefit does not exist, is no longer effective, or is not appropriate. Indications for monotherapy include platinum resistant epithelial ovarian cancer (EOC), gastric/gastroesophageal junction (GEJ) cancer, squamous cell carcinoma of the head and neck (HNSCC), recurrent and either metastatic or unresectable melanoma, non-small cell lung cancer (NSCLC), metastatic castration-resistant prostate cancer (mCRPC), malignant pleural mesothelioma (MPM), triple-negative breast cancer (TNBC), locally advanced or metastatic urothelial cancer, cervical cancer, and microsatellite stable colorectal cancer (MSS CRC), and diffuse large cell B-cell lymphoma (DLBCL) including patients with Richter transformation (DLBCL-RT). Indications for paclitaxel combo may include, but are not limited to, platinum-resistant EOC, gastric/GEJ cancer, HNSCC, NSCLC, TNBC, locally advanced or metastatic urothelial cancer, and cervical cancer at the Sponsor's discretion. Phase 1b will investigate the efficacy of NX-1607 as monotherapy or in combination with paclitaxel at the dose(s) selected in Phase 1a in up to 8 cohorts of patients with select advanced malignancies for which standard therapy, including immunotherapy, with proven clinical benefit does not exist, is no longer effective, or is not appropriate. Indications include platinum-resistant EOC, including primary peritoneal and fallopian tube carcinoma, advanced gastric/GEJ cancer, HNSCC, recurrent and either metastatic or unresectable melanoma, advanced NSCLC, mCRPC, mixed solid tumor cohort indications consisting of patients with MPM, TNBC, locally advanced or metastatic urothelial cancer, cervical cancer, or MSS CRC, and DLBCL including patients with DLBCL-RT.


Recruitment information / eligibility

Status Recruiting
Enrollment 345
Est. completion date February 28, 2026
Est. primary completion date August 31, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Key Inclusion Criteria: - Age = 18 years. - Measurable disease per disease-specific response criteria. - Patients must have disease that is metastatic or unresectable and have received standard treatment options, are not candidates for standard treatment options, or will otherwise be prevented from receiving any standard treatment options. - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. - Minimum of 3 weeks or 5 half-lives (whichever is shorter) since last dose of systemic cancer therapy (unless otherwise specified) or minimum of 2 weeks since last radiotherapy, or minimum of 6 weeks since last systemic therapy with nitrosoureas, antibody-drug conjugate, or radio immuno-conjugate therapy. - Adequate organ and bone marrow function, in the absence of growth factors (with limited exception for DLBCL), as defined by laboratory parameters. - Patients of child-bearing potential must use adequate contraceptive measures to avoid pregnancy for the duration of the study as defined in the protocol. - Patient must be willing and able to adhere to the prohibitions and restrictions specified in the protocol. - Each patient must sign an informed consent form (ICF). - Histological or cytological diagnosis of platinum-resistant EOC, including primary peritoneal and fallopian tube carcinoma; gastric/GEJ cancer; HNSCC; recurrent and either metastatic or unresectable melanoma; NSCLC; mCRPC; MPM; TNBC; locally advanced or metastatic urothelial cancer; cervical cancer; MSS CRC; or DLBCL (including DLBCL-RT) - Accessible tumor (for all cohorts) or lymph node (DLBCL only) for biopsy (Phase 1b only). Key Exclusion Criteria: - Active untreated brain metastases. - Patient has any of the following: - Uncontrolled intercurrent illness including, but not limited to, poorly controlled hypertension or diabetes, or ongoing active infection requiring systemic therapy. - Patients with primary refractory EOC defined as patients who do not respond to their first platinum-containing regimen or who relapse less than 6 months after completion of that first platinum-containing regimen - Psychiatric illness that would limit compliance with study requirements. - Treatment with any of the following prior to the first dose of NX-1607: CPI (anti-PD-1, PD-L1, cytotoxic T-lymphocyte-associated protein 4, etc) within 3 weeks; autologous or allogeneic stem cell transplant within 100 days; prior systemic cancer therapy within 3 weeks or 5 half-lives (whichever is shorter) (unless otherwise specified) (including hormonal therapy except for hormonal prophylaxis for a prior malignancy); prior radiotherapy within 2 weeks; prior systemic therapy with nitrosoureas, antibody-drug conjugate, or radio-immuno-conjugate therapy within 6 weeks; use of strong or moderate CYP3A4 inducers or inhibitors within 14 days or 7 days, respectively, or 5 half-lives (whichever is longer) - History of CAR-T therapy within 30 days prior to the first dose of NX-1607. - Toxicities from previous anti-cancer therapies that have not resolved to baseline levels or to Grade 1 or less except for Grade 2 alopecia and Grade 2 peripheral neuropathy or patients receiving endocrine replacement therapy - Patients who experienced Grade 3 or higher irAEs with prior immunotherapy. - History of uveitis, or an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed. - Unable to swallow capsules or has malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel or ulcerative colitis, symptomatic inflammatory bowel disease, or partial or complete bowel obstruction likely to interfere with the delivery, absorption, or metabolism of NX-1607. - Known allergies, hypersensitivity, or intolerance to components of NX-1607. - Pregnant, breastfeeding, or planning to become pregnant while enrolled in this study or within 6 months after the last dose of NX-1607. - Patient is a man who plans to father a child while enrolled in this study or within 3 months after the last dose of NX-1607 and, as applicable, within 6 months after the last dose of paclitaxel. - Patient has had major surgery (e.g., requiring general anesthesia) within 4 weeks before the planned first dose of NX-1607, or will not have fully recovered from surgery, or has surgery planned during the time the patient is expected to participate in the study or within 4 weeks after the last dose of NX-1607. Note: Patients with minor planned surgical procedures to be conducted under local anesthesia may participate. - Vaccinated with a live vaccine within 28 days (with the exception of the annual inactivated influenza vaccine) or COVID-19 vaccination within 14 days prior to the first dose of NX-1607. - Active known second malignancy with the exception of any of the following: - Adequately treated basal cell carcinoma, squamous cell carcinoma of the skin, or in situ cervical cancer. - Adequately treated Stage I cancer from which the patient is currently in remission and has been in remission for = 2 years. - Low-risk prostate cancer with Gleason score < 7 and PSA < 10 ng/mL. - Any other cancer from which the patient has been disease-free for = 2 years. - Infection with human immunodeficiency virus (HIV)-1 or HIV-2. Exception: Patients with well controlled HIV (e.g., CD4 > 350/mm3 and undetectable viral load) are eligible. - Current active hepatitis, including hepatitis A (hepatitis A virus immunoglobulin M [IgM] positive), hepatitis B (hepatitis B virus [HBV] surface antigen positive), or hepatitis C (hepatitis C virus [HCV] antibody positive, confirmed by HCV RNA). Patients with HCV with undetectable virus after treatment are eligible. Patients with prior exposure to HBV may be entered if quantitative PCR is negative. - Use of systemic corticosteroids (> 20 mg prednisone or equivalent) within 15 days (except for prophylaxis for radio diagnostic contrast reactions and/or prophylaxis for patients receiving paclitaxel), or other immunosuppressive drugs within 30 days, prior to the first dose of NX-1607. - Use of biotin (i.e., Vitamin B7) or supplements containing biotin higher than the daily adequate intake of 30 µg [NIH 2020] (Note: Patients who switch from a high dose to a dose of 30 µg/day or less at least 1 day prior to Screening assessments are eligible for study entry). - Receipt of an IP or has been treated with an investigational device within 3 weeks or 5 half-lives (whichever is shorter) prior to the first dose of NX-1607. - Any of the following within 6 months prior to the first dose of NX-1607 or ongoing: - Myocardial infarction - Unstable angina - Unstable symptomatic ischemic heart disease - New York Heart Association Class III or IV heart failure - Thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism, or symptomatic cerebrovascular events) - Any other significant cardiac condition (e.g., pericardial effusion, restrictive cardiomyopathy, severe untreated valvular stenosis, or severe congenital heart disease) - Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the participant's participation for the full duration of the study, or is not in the best interest of the participant to participate, in the opinion of the treating Investigator in consultation with the Medical Monitor.

Study Design


Related Conditions & MeSH terms

  • Carcinoma
  • Carcinoma, Ovarian Epithelial
  • Cervical Cancer
  • Colorectal Neoplasms
  • Diffuse Large B Cell Lymphoma (DLBCL)
  • Gastric Cancer
  • Head and Neck Squamous Cell Carcinoma
  • Lymphoma
  • Lymphoma, Large B-Cell, Diffuse
  • Malignant Pleural Mesothelioma (MPM)
  • Mesothelioma
  • Mesothelioma, Malignant
  • Metastatic Castration-resistant Prostate Cancer (mCRPC)
  • Metastatic or Unresectable Melanoma
  • Metastatic Urothelial Carcinoma
  • Microsatellite Stable Colorectal Carcinoma
  • Neoplasms
  • Non-small Cell Lung Cancer (NSCLC)
  • Ovarian Cancer, Epithelial
  • Richter Transformation
  • Squamous Cell Carcinoma of Head and Neck
  • Triple Negative Breast Cancer (TNBC)
  • Triple Negative Breast Neoplasms

Intervention

Drug:
NX-1607
Oral NX-1607
Paclitaxel
Paclitaxel IV

Locations

Country Name City State
United Kingdom University College London Hospitals NHS Foundation Trust Bloomsbury
United Kingdom Addenbrookes Cambridge University Hospital Cambridge
United Kingdom Beatson West of Scotland Cancer Centre Glasgow
United Kingdom Sarah Cannon Research Institute London
United Kingdom The Christie NHS Foundation Trust Manchester
United Kingdom Northern Centre for Cancer Care Newcastle
United Kingdom Churchill Hospital Oxford
United Kingdom Royal Marsden Hospital NHS Foundation Trust Sutton Surrey
United States University of Colorado School of Medicine Aurora Colorado
United States University of North Carolina Chapel Hill North Carolina
United States University of Virginia Charlottesville Virginia
United States University of Chicago Chicago Illinois
United States City of Hope Duarte California
United States MD Anderson Cancer Center Houston Texas
United States University of Southern California Los Angeles California
United States Memorial Sloan Kettering Cancer Center New York New York
United States University of Oklahoma Oklahoma City Oklahoma
United States University of California, San Francisco San Francisco California
United States Fred Hutchinson Cancer Center Seattle Washington
United States Swedish Cancer Institute Seattle Washington

Sponsors (1)

Lead Sponsor Collaborator
Nurix Therapeutics, Inc.

Countries where clinical trial is conducted

United States,  United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Incidence of treatment-emergent adverse events (TEAEs), including Grade = 3 TEAEs, treatment-emergent serious adverse events (SAEs), TEAEs leading to study drug discontinuation, and deaths due to TEAEs Phase 1a 16 months
Primary Incidence of immune-related AEs (irAEs), all deaths, and dose-limiting toxicities (DLTs) Phase 1a Up to 2 Years
Primary Objective Response Rate (ORR) per disease-specific response criteria as assessed by the Investigator Phase 1b Up to 3 Years
Secondary PK parameters of NX-1607: area under the curve (AUC) Phase 1a/1b - Sampling following the first dose, pre and post-dose at selected cycles, and at the end of treatment Up to 3 Years
Secondary PK parameters of NX-1607: apparent clearance (CL/F) Phase 1a/1b - Sampling following the first dose, pre and post-dose at selected cycles, and at the end of treatment Up to 3 Years
Secondary PK parameters of NX-1607: maximum plasma concentration (Cmax) Phase 1a/1b - Sampling following the first dose, pre and post-dose at selected cycles, and at the end of treatment Up to 3 Years
Secondary PK parameters of NX-1607: volume of distribution Phase 1a/1b - Sampling following the first dose, pre and post-dose at selected cycles, and at the end of treatment Up to 3 Years
Secondary PK parameters of NX-1607: half-life and time to maximum plasma concentration Phase 1a/1b - Sampling following the first dose, pre and post-dose at selected cycles, and at the end of treatment Up to 3 Years
Secondary PK parameters of NX-1607: accumulation ratio (Racc) Phase 1a/1b - Sampling following the first dose, pre and post-dose at selected cycles, and at the end of treatment Up to 3 Years
Secondary PD Biomarkers: Changes from baseline in inflammatory cytokine expression in the circulating immune cells Phase 1a/1b - Sampling following the first dose, pre and post-dose at selected cycles, and at the end of treatment Up to 3 Years
Secondary Objective response rate (ORR) per disease-specific response criteria as assessed by the Investigator Phase 1a Up to 3 Years
Secondary Duration of response (DOR) as assessed by the Investigator Phase 1a/1b Up to 3 Years
Secondary Disease control rate (DCR) as assessed by the Investigator Phase 1a/1b Up to 3 Years
Secondary Progression-free survival (PFS) as assessed by the Investigator Phase 1a/1b Up to 3 Years
Secondary Overall survival (OS) as assessed by the Investigator Phase 1a/1b Up to 3 Years
Secondary Incidence of TEAEs, including Grade = 3 TEAEs, treatment emergent SAEs, TEAEs leading to study drug discontinuation, and deaths due to TEAEs Phase 1b Up to 3 Years
Secondary Time to disease progression assessed by the Investigator (according to relevant disease histology) Phase 1b Up to 3 Years
Secondary Incidence of IrAEs and all deaths Phase 1b Up to 3 Years
Secondary Time from start of treatment to disease progression based on PCWG3 criteria Phase 1b (mCRPC cohort only) Up to 3 Years
Secondary PD Biomarkers: Changes from baseline in tumor tissue biopsies of immune cell infiltration or other histological features Phase 1b Up to 3 Years
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