Gastric Adenocarcinoma Clinical Trial
Official title:
Phase II Trial of Gleevec (Imatinib Mesylate) and Taxotere (Docetaxel) as a Combined Regimen for Advanced Gastric Adenocarcinoma
The purpose of this trial is to test the combination of Gleevec® (also known as imatinib mesylate) and Taxotere (also known as docetaxel) in patients with incurable stomach cancer. This study is being performed to see if the combination of Gleevec and Taxotere is an effective treatment for incurable stomach cancer with minimal side effects.
The purpose of this trial is to test the combination of Gleevec® (also known as imatinib
mesylate) and Taxotere (also known as docetaxel) in patients with incurable stomach cancer.
Gleevec is a pill form of chemotherapy and is indicated for the treatment of adult patients
with chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It is
considered experimental for the treatment of stomach cancer. Taxotere (docetaxel) is a
chemotherapy which is injected into the vein. It is approved for breast and lung cancer but
has been shown to shrink many different types of tumors. Taxotere has been shown to shrink
stomach cancer in about 20% - 30% of patients treated with Taxotere only. This study is
being performed to see if the combination of Gleevec and Taxotere is an effective treatment
for incurable stomach cancer with minimal side effects.
Treatment on this study consists of two drugs, Gleevec® and Taxotere. Patients will be take
four tablets of Gleevec® daily throughout the study. After one week of Gleevec®, patients
will then begin receiving doses of Taxotere intravenously once a week for two weeks in a row
followed by one week without Taxotere.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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