Gambling Disorder Clinical Trial
Official title:
Exploring the Role and Neural Mechanisms of Transcranial Temporal Interference Stimulation Modulating the Dorsal Anterior Cingulate Cortex on Risky Decision-making and Impulse Control in Gambling Disorder
The purpose of this research is to investigate the effect of transcranial temporal interference stimulation (tTIS) targeting the dorsal anterior cingulate cortex in patients with gambling disorder.
Status | Not yet recruiting |
Enrollment | 30 |
Est. completion date | June 1, 2025 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Aged 18-60, male or female, right handed; - With 9 or more years of education, and able to cooperate in completing the questionnaire assessment and behavioural tests. - Meets the DSM-5 diagnostic criteria for gambling addiction; - Previous gambling behaviour of not less than 1 year's duration (at least one gambling session per week or more); - Normal or corrected normal vision and hearing; - Agrees to cooperate in completing the follow-up assessment; - No history of neurological problems or head injury; and no skin sensitivity. - Agree to cooperate in completing the follow-up assessment; - No metal implantation in the head, no history of neurological problems or head injury, and no skin sensitivity. Exclusion Criteria: - Suffering from severe cognitive dysfunction, such as a history of head trauma, cerebrovascular disease, epilepsy, etc., use of cognitive-promoting medications in the last 6 months; - Other psychoactive substance abuse or dependence in the last 5 years (except nicotine). |
Country | Name | City | State |
---|---|---|---|
China | Shanghai Mental Health Center | Shanghai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai Mental Health Center |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Activation of dACC | Activation of dACC is measured with resting-state fMRI and task fMRI. | Through the fMRI procedure | |
Primary | Activation of decision-making network | Activation of decision-making network is measured with resting-state fMRI and task fMRI connectivity analysis. | Through the fMRI procedure | |
Primary | The change of impulsivity | The change of impulsivity will be measured by sequential decision-making task. | Through the last 20 minutes of the fMRI session. | |
Secondary | The change of gambling craving | Gambling craving will be measured by the gambling craving Visual Analog Scale (VAS). The total score of VAS ranged from 0 to 10, in which higher scores mean a higher level of gambling craving. | 8 minutes, 16 minutes, 24 minutes, 44 minutes of the fMRI session. |
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