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Effect of Palonosetron on Remifentanil for Preventing Emergence Cough in Female

Gallbladder Diseases Clinical Trial

Official title:
Effect of Palonosetron on Effect-site Concentration of Remifentanil for Preventing Emergence Cough During General Anesthesia in Female Patients Undergoing Laparoscopic Cholecystectomy

Clinical Trial Summary

The primary purpose of this study is to investigate the optimal Ce of remifentanil for preventing emergence cough following extubation during general anesthesia in female patients who receive the palonosetron or not.

Clinical Trial Description

Remifentanil is a potent ultrashort-acting opioid, with rapid onset and offset of drug effect. It allows rapid anesthetic emergence even after a prolonged infusion, and decreases the at-risk time during extubation. In addition, cough suppression of remifentanil enables smooth extubation with reduced complications. However, the infusion of remifentanil suppresses the emergence cough effectively in clinical practice, whereas it still delays the awakening from anesthesia, resulting in prolonged emergence time. Reduced Ce of remifentanil during emergence would decrease the adverse events that are associated with remifentanil infusion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04563260
Study type Interventional
Source Ajou University School of Medicine
Contact
Status Completed
Phase N/A
Start date October 7, 2020
Completion date March 19, 2021
View Details
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