G6PD Deficiency Clinical Trial
Official title:
Effects of Alpha Lipoic Acid Supplementation in G6PD Deficient Individuals After Acute Exercise
The purpose of this study is to investigate the effects of alpha-lipoic acid supplementation on redox status, physiological and biochemical parameters in G6PD deficient individuals after acute exercise.
In a randomized double-blind, crossover design, 12 adult volunteers with G6PD deficiency of
both sexes will be supplemented with either 600 mg of alpha-lipoic acid (experimental
condition - EC) or placebo (control condition - CC) every day for 4 weeks. Before
intervention, all participants will be informed about the study protocol, fill a medical
history questionnaire and sign an informed consent form. Moreover, measurements of
anthropometric characteristics and physiological parameters, as well as a VO2max test will be
performed.
Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion)
before and after each condition. Blood samples will be collected before, immediately after
and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and
physiological parameters will be performed before and after each condition. There will be a
washout period of at 4 weeks between conditions.
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