Furcation Defects Clinical Trial
Official title:
Efficacy of Platelet Rich Fibrin as a Graft and Membrane Versus Hyaluronic Acid and Amniotic Membrane in the Treatment of Mandibular Grade II and Grade III Furcation Defects- A Randomized Clinical Trial
This study is intended to compare the efficacy of platelet-rich fibrin as a graft and a membrane versus hyaluronic acid(Gengigel) and amniotic membrane in the treatment of mandibular grade II furcation defects.
Platelet-rich fibrin is a fraction of plasma that provides a rich source of growth factors
and may enhance the stabilization and revascularization of the flaps and grafts.
Hyaluronic acid is a naturally occurring non-sulfated high molecular weight glycosaminoglycan
that forms a critical component of the extracellular matrix and contributes significantly to
tissue hydrodynamics, cell migration and proliferation. Hence its administration to
periodontal wound sites could achieve beneficial effects in periodontal tissue regeneration.
Amniotic membrane is being used for various regenerative procedures as it is a rich source of
various collagen and non-collagen proteins such as laminin, fibronectin and proteoglycan.
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Status | Clinical Trial | Phase | |
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N/A | |
Completed |
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Phase 4 | |
Not yet recruiting |
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Recruiting |
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Active, not recruiting |
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