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NCT03180658 Clinical Trial

Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans

Furcation Defects Clinical Trial

Official title:
The Effect of Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03180658
Other study ID # 81600868
Secondary ID
Status Recruiting
Phase N/A
First received May 29, 2017
Last updated June 7, 2017
Start date May 1, 2017
Est. completion date July 1, 2020

Study information
Verified date June 2017
Source Peking University
Contact qiao jing, doctor
Phone 86-13241892143
Email donaldshushu@aliyun.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Objective: To compare the effect of guided tissue regeneration (GTR) + concentrated growth factors (CGF) + bone graft and CGF + bone graft in the treat of II° furcations of human mandibular molars. Methods: At least thirty II°furcation involvements in mandibular molars will be included and randomly divided into two groups. The experimental group will accept GTR + CGF + bone graft therapy, and the control group will accept CGF + bone graft therapy. The clinical examination and cone beam computed tomography (CBCT) will be performed at baseline and 1 year post-surgery.

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date July 1, 2020
Est. primary completion date May 1, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- II° furcation involvements in mandibular molars

- after periodontal therapy.

Exclusion Criteria:

- not healthy

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• GTR + CGF + bone graft
Guided tissue regeneration (GTR) combined with CGF and bone graft to treat mandibular furcation involvements
• CGF + bone graft
CGF combined with bone graft to treat mandibular furcation involvements

Locations
Country Name City State
China Peking university School and Hospital of Stomatology Beijing Beijing

Sponsors (1)
Lead Sponsor Collaborator
Jing Qiao

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary clinical measurement Probing depth 1 year
Primary clinical parameter clinical attachment loss 1 year
Secondary radiographic parameter cone beam computerized tomographic scanning 1 year
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04851548 - Evaluate the Effect of Hyaluronic Acid in the Treatment of Furcation Involvement N/A
Completed NCT03207698 - PRF+1% MF for Class II Mandibular Furcation Defects Phase 2/Phase 3
Recruiting NCT06025955 - Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement. N/A
Not yet recruiting NCT05721313 - Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study N/A
Not yet recruiting NCT05481580 - Restorations and Furcation Involvement on Molars
Recruiting NCT06060340 - Clinical and Radiographic Outcomes of Class II Furcation Defects Management Using Propolis: A Case Series Early Phase 1
Recruiting NCT05541614 - Flapless Application of Enamel Matrix Derivative in Class II Mandibular Furcation Defects N/A
Terminated NCT04059445 - Mandibular Furcation II Regeneration Phase 4
Terminated NCT04059458 - Mandibular Furcation III Regeneration (FURC-III-REGEN) Phase 4
Withdrawn NCT03917030 - Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade II Furcation Defects N/A
Withdrawn NCT04017429 - Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade III Furcation Defects (FURC-III-OST) N/A
Completed NCT02369250 - Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects Phase 4
Not yet recruiting NCT06116487 - MRI as Alternative to CBCT for the Assessment of Furcation Involvement in Molars
Completed NCT03578744 - Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects N/A
Active, not recruiting NCT05259982 - Vital Root-resective Therapy in Furcation-involved Maxillary Molars N/A
Active, not recruiting NCT02132806 - Piezosurgery in the Treatment of Class II Furcation Involvement N/A
Completed NCT02102360 - Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial. Phase 4
Not yet recruiting NCT06270303 - Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects N/A
Completed NCT03354182 - Surgical Treatment of Mandibular Furcations Using a Xenograft With/Without a Collagen Membrane N/A
Completed NCT04842188 - Furcation Treatment With L-PRF and aPDT N/A