Furcation Defects Clinical Trial
Official title:
Platelet Rich Fibrin Combined With 1.2% Atorvastatin Gel in Treatment of Mandibular Degree II Furcation Defects: a Randomized Controlled Clinical Trial
The present study was designed to explore the effectiveness of PRF combined with 1.2% ATV gel in treatment of mandibular degree II furcation defects in comparison to PRF and open flap debridement (OFD) alone.
Background: A variety of regenerative materials have been tried since many years for the
treatment of furcation defects. Platelet-rich fibrin (PRF), a pool reservoir of platelet
concentrate with growth factors and Atorvastatin (ATV), a potent member of statin group are
known to promote periodontal tissue regeneration. The aim of the present study is to explore
the effectiveness of PRF combined with 1.2% ATV gel in treatment of mandibular degree II
furcation defects in comparison to PRF and open flap debridement (OFD) alone.
Methods: Eighty two mandibular furcation defects were treated with either OFD alone (Group
1), OFD with PRF (Group 2), and OFD with PRF+1.2% ATV gel (Group 3).Clinical parameters like
probing depth (PD), relative vertical clinical attachment level (RVCAL), relative horizontal
clinical attachment level (RHCAL), modified sulcus bleeding index (mSBI) and site specific
plaque index (PI) were recorded at baseline and 9 months post-operatively. The radiological
assessment of bone defect fill was done at baseline and 9 months, using computer-aided
software.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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