Full Thickness Skin Defects Clinical Trial
Official title:
Clinical Application of a Novel Dermal Substitute Based on Glycerol Preserved Allograft: GLYADERM
The application of Glyaderm for skin restoration intends to provide a more stable wound
closure with enhanced pliability and function of the skin and a more favourable scar. The
dermal substitute would be affordable for widespread application in full thickness skin
defects and burns.
Patients with burn wounds or large full thickness wounds will be evaluated before
enrollment. All burn wounds that are not clearly full thickness on clinical assessment will
be treated during the first 48 hours with a hydrocolloid paste and covered with a paraffin
gauze dressing. This hydrocolloid paste combined with paraffin gauze will ensure maintenance
of a moist wound environment for the first 48 hours prior to assessment by LDI and
randomization. This is the standard treatment for all burns admitted to the Ghent Burn
Centre.
Wounds will be photographed on a daily basis. In order to obtain an optimal preparation for
LDI, the burn wounds will be meticulously debrided during dressing changes. LDI is most
reliable between 48-72 hours. Patients whose burn wounds meet the inclusion criteria, i.e.
full thickness burns with LDI values < 200 will be randomized to receive either GLYADERM and
split skin graft versus split skin graft alone.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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The Safety of a Novel Acellular Dermal Template as Treatment for Burns and Scars
|
N/A | |
Completed |
NCT02373566 -
A Study to Evaluate the Efficacy of an Acellular Dermal Template for the Treatment of Full Thickness Skin Defects
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N/A |