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OCT-guided DSAEK Graft Shaping and Smoothing — DSAEK  

Fuchs' Endothelial Dystrophy Clinical Trial

Official title:
Randomized Clinical Trial of OCT-guided DSAEK Graft Shaping and Smoothing

Clinical Trial Summary

The primary goal of this study is to determine if excimer laser smoothing of the cornea before Descemet's stripping automated endothelial keratoplasty (DSAEK)improves postoperative Best Spectacle Corrected Visual Acuity (BSCVA).

Clinical Trial Description

Many surgeons are moving away from full thickness corneal transplantation (because of risks involving rejection, irregular astigmatism, and wound dehiscence) to partial thickness transplantations of either the anterior or posterior (endothelial) layers. However this technique is not without its drawbacks. DSAEK uses a mechanical microkeratome to cut the graft, but vision is limited by the roughness of the cut surface.

DSAEK can lead to significant refractive error due to the non-uniform shape of the microkeratome cut graft, and the roughness of the microkeratome cut surface limits vision to an average of 20/31. Optical coherence tomography (OCT)-guided laser shaping and smoothing may improve the refractive and visual outcome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01586234
Study type Interventional
Source Oregon Health and Science University
Contact
Status Terminated
Phase N/A
Start date January 2012
Completion date August 31, 2014
View Details
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