Clinical Trials Logo
  1. Home
  2. Fructose Intolerance
  3. NCT02085889

Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders

Functional Gastrointestinal Disorders Clinical Trial

Official title:
Fructose and Lactose Intolerance and Malabsorption: the Relationship Between Metabolism and Symptoms in Functional Gastrointestinal Disorders

Clinical Trial Summary

Background: The association of fructose and lactose intolerance and malabsorption with the symptoms of different functional gastrointestinal disorders (FGID) is unclear. The mechanisms behind the multi-organ symptoms remain unclear. Both FGID and saccharide intolerances are common (>10% of any given population). Dietary modification based on intolerance diagnostics could provide an effective treatment for FGID, which are otherwise difficult to treat. Aim: To investigate the prevalence and interrelationships of fructose and lactose intolerance (symptom induction) and malabsorption (breath test gas production) and their association with clinical GI as well as non-GI symptoms in FGID and the outcome of standard dietary intervention. Mechanisms related to symptom genesis will be investigated using metabolomic analysis of plasma and urine by gas chromatography/time-of-flight mass spectrometry (GC/TOFMS). Methods: Fructose and lactose intolerance (defined by positive symptom index) and malabsorption (defined by increased hydrogen/methane) will be determined in successive male and female FGID patients in a single center using breath-testing. Symptoms will be recorded using standardised questionnaires and the Rome III criteria. The prevalence of the intolerances in the different FGID subgroups and the associations between breath testing results, clinical symptoms and the outcome of dietary modification will be assessed. Factors predictive of the outcome of dietary modulation will be screened for. GC/TOFMS will be used to assess the human and microbial metabolome in urine and plasma.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02085889
Study type Observational
Source Brain-Gut Research Group
Contact Clive Wilder-Smith, MD
Phone +41313123737
Email info@ggp.ch
Status Recruiting
Phase
Start date March 1, 2019
Completion date December 2022
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT05936112 - Quantification of Fecal Calprotectin Concentration Difference Between Infants Aged Under 4 Months Old Suffering From Functional Gastrointestinal Disorders (FGID) and Infants Aged Under 4 Months Old Free From Disorders : a Transversal Case-control Monocentric Study N/A
Completed NCT02565355 - Targeted Food Elimination for Treatment of Functional Gastrointestinal Diseases in Children N/A
Completed NCT02657668 - Emotion Focused Therapy in Irritable Bowel Syndrome Patients N/A
Completed NCT02731664 - GLP-1 Inhibits Prandial Antro-duodeno-jejunal Motility in Humans Phase 1
Recruiting NCT06205446 - Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction N/A
Recruiting NCT05718960 - Traditional Dietary Advice Versus Reassurance-alone in Postprandial Functional Dyspepsia N/A
Terminated NCT04247100 - A Study of Randomized Sham-control Auricular TENS Unit Stimulation in Pediatric Functional Gastrointestinal Disorders N/A
Recruiting NCT03625674 - Impact of Stigma on Compliance to Medication in Functional Dyspepsia N/A
Completed NCT03252743 - ICBT for Pain-predominant FGIDs in Children and Adolescents: an Implementation Study. N/A
Recruiting NCT05832528 - Low FODMAP Diet in FD (PDS) N/A
Completed NCT02936713 - Effect of Controlled Diet Combined With a Fermented Milk Product on Gas-related Symptoms N/A
Terminated NCT01712412 - Phase 2a Study of IW-9179 to Treat Functional Dyspepsia Phase 2
Completed NCT00564525 - Study of Medication for Functional Abdominal Pain in Children Phase 4
Recruiting NCT05987813 - Transcutaneous Electric Nerve Stimulation (TENS) for Vagal Modulation N/A
Completed NCT04155801 - A Study to Assess the Efficacy and Safety of Salix Probiotic Blend in Participants With Functional Gastrointestinal Disturbances N/A
Recruiting NCT05880199 - BSGM to Evaluate Patients With GI Symptoms
Recruiting NCT04625881 - Effects of an Apple Derived Fibre Supplement on Constipation Phase 3
Completed NCT03608735 - Prevalence of Functional Gastrointestinal Disorders (FGIDs), Related Signs and Symptoms in Infants/Toddlers in Thailand
Recruiting NCT04773158 - Systematic Pediatric Assessment of Rome Criteria N/A
Completed NCT02306369 - Internet-delivered CBT for Irritable Bowel Syndrome in Adolescents N/A