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Frontotemporal Dementia clinical trials

View clinical trials related to Frontotemporal Dementia.

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NCT ID: NCT04187391 Active, not recruiting - Clinical trials for Primary Progressive Aphasia

The Effects of a Multimodal Approach for the Treatment of Primary Progressive Aphasia

ACROSS
Start date: January 15, 2020
Phase: N/A
Study type: Interventional

Primary Progressive Aphasia (PPA) is an untreatable neurodegenerative disorder that disrupts language functions. Available therapies are mainly symptomatic and recently attention has been gained by new techniques that allow for noninvasive brain stimulation such as transcranial direct current stimulation (tDCS). The primary objective of this study is to evaluate whether the application of Active tDCS (anode over the left dorsolateral prefrontal cortex- DLPFC with the cathode over the right supraorbital region) to the scalp during individualized language training, would improve naming abilities in the agrammatic variant of PPA (avPPA) more than use of one methodology alone. The effect of treatment on the clinical symptoms will be related to changes in brain activity (Magnetic Resonance Imaging, MRI and Functional near-infrared spectroscopy fNIRS) and in biological markers, using a multimodal approach. Finally, we will assess the long-term effects of this approach.

NCT ID: NCT03987295 Active, not recruiting - Clinical trials for Frontotemporal Dementia

A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)

Start date: September 27, 2019
Phase: Phase 2
Study type: Interventional

A Phase 2 open label study evaluating the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AL001 in participants with a Granulin mutation or C9orf72 mutation causative of frontotemporal dementia.

NCT ID: NCT03912987 Active, not recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

TRIAL READY (Clinical Trial Readiness)

Start date: January 22, 2019
Phase:
Study type: Observational

This study, being conducted under the auspice of the CReATe Consortium, will enroll patients with ALS and related disorders as well as healthy controls, with the goal of facilitating clinical validation of leading biological-fluid based biomarker candidates that may aid therapy development for patients with ALS and related disorders.

NCT ID: NCT03893071 Active, not recruiting - Clinical trials for Niemann-Pick Disease, Type C1

Open-Label Study of Long-Term Safety and Efficacy of Intravenous Trappsol Cyclo (HPβCD) in Niemann-Pick Disease Type C

Start date: May 23, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to provide continued access to treatment for NPC-1 after participation and completion of the Phase I trial CTD-TCNPC-101, when administered at doses of 1500 mg/kg and 2500 mg/kg by slow IV infusion over a period of 8 to 9 hours every two weeks.

NCT ID: NCT03260920 Active, not recruiting - Clinical trials for Frontotemporal Dementia

Intranasal Oxytocin for Frontotemporal Dementia

FOXY
Start date: January 31, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety, tolerability and effects on behaviour of Syntocinon given intranasally (by a spray into the nostrils) compared to placebo (an inactive saline substance that contains no medication) in participants with frontotemporal dementia/Pick's disease. This study will take place in approximately 15 centres across Canada and the United States. Approximately 112 patients in total will be enrolled in this study. In the first phase we will examine which of three different dosing schedules of oxytocin may be more effective. In the second phase of the study, patients entering the study will be randomized to the oxytocin dosing schedule that appeared most effective in the first phase.

NCT ID: NCT03174886 Active, not recruiting - Clinical trials for Primary Progressive Nonfluent Aphasia

A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia

AIDA
Start date: July 31, 2017
Phase: Phase 1
Study type: Interventional

This study is a pilot trial evaluating the safety and immunogenicity of AADvac1 in patients with the non-fluent variant of Primary Progressive Aphasia. 50% of participants will receive the 40 µg dosage of AADvac1 and 50% of participants will receive the 160 µg dosage of AADvac1. No placebo is used.

NCT ID: NCT02966145 Active, not recruiting - Clinical trials for Progressive Supranuclear Palsy (PSP)

4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2

4RTNI-2
Start date: January 2016
Phase:
Study type: Observational

The goal of this study is to identify the most reliable methods of analysis for tracking CBD, PSP, and o/vPSP over time. The results from this study may be used in the future to calculate statistical power for clinical drug trials. The study will also provide information about the relative value of novel imaging techniques for diagnosis, as well as the value of imaging techniques versus testing of blood, urine, and cerebrospinal fluid (CSF) 'biomarkers'.

NCT ID: NCT02675270 Active, not recruiting - Alzheimer Disease Clinical Trials

Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia

Start date: November 2011
Phase: N/A
Study type: Interventional

The goal of this study is to remediate word-finding problems in patients who have Primary Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which the investigators attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. One set of participants with PPA will receive practice with picture naming in two conditions: viewing the picture and repeating the name; and viewing the picture with its written name, plus reading and writing the name. Another set of participants with PPA or Alzheimer's Disease will be trained in two different conditions: learning about the word's semantic features (meaning); and learning about the word's lexical features (letters and sounds). Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Furthermore, it is predicted that participants who have difficulty understanding concepts will be more likely to respond to semantic treatment, while participants who have difficulty connecting words with concepts will be more likely to respond to lexical treatment.

NCT ID: NCT02612129 Active, not recruiting - Clinical trials for Niemann-Pick Disease, Type C

Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C

Start date: June 14, 2016
Phase: Phase 2/Phase 3
Study type: Interventional

A prospective, randomized, double-blind, placebo controlled therapeutic study in participants with confirmed diagnosis of Niemann-Pick disease type C (NPC). The purpose of this study is to assess the efficacy and safety of arimoclomol (compared to placebo) when it is administered as an add-on therapy to the participant's current prescribed best routine clinical care; participant's routine clinical care may, or may not, include miglustat. The CT-ORZY-NPC-002 study has been expanded to include an open label paediatric sub-study including participants aged 6 to <24 months at study enrolment.

NCT ID: NCT02149160 Active, not recruiting - Granulin Mutation Clinical Trials

Study to Assess the Safety, Tolerability, and Pharmacodynamic (PD) Effects of FRM-0334 in Subjects With Prodromal to Moderate Frontotemporal Dementia With Granulin Mutation

Start date: October 2014
Phase: Phase 2
Study type: Interventional

The purposes of this study are to investigate the safety, tolerability, and pharmacodynamics of FRM-0334 in subjects with prodromal to moderate frontotemporal dementia with granulin mutation.