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Free Flap clinical trials

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NCT ID: NCT06313385 Active, not recruiting - Clinical trials for Temperature Change, Body

Investigating the Impact of Indocyanine Green Titration on Fluorescent Intensity in Free Flap : An Exploration of Alternative Indicators

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

This study is a randomized clinical trials that aim to determine the effect of Indocyanine Green (ICG) titration dose on the intensity degree of ICG fluorescence imaging results. In addition, this study will also determine the relationship of other indicators such as flap surface temperature, transcutaneous pressure of carbon dioxide (TcPCO2), transcutaneous pressure of oxygen (TcPCO2), HIF - 1 alpha expression, and flap histopathology morphology to the intensity degree of ICG fluorescence imaging results with titrated doses.

NCT ID: NCT04023474 Completed - Clinical trials for Head and Neck Disorder

Platelet-Rich Fibrin in the Healing of Regional and Free Flaps

Start date: December 16, 2019
Phase: N/A
Study type: Interventional

Determine if the use of platelet-rich fibrin (PRF) versus historical treatment methods improves the post-operative management of healing complications from flap donor sites.

NCT ID: NCT02526342 Completed - Edema Clinical Trials

Impact of Negative Pressure Wound Therapy on Free Muscle Flaps

Start date: August 1, 2015
Phase: N/A
Study type: Interventional

Aim of the study is to prove the utility and safety of the negative pressure wound therapy (NPWT) in the postoperative management of free flaps. The quantitative assessment of the entirety of clinical main relevant parameters like edema formation, microcirculation, macrocirculation and wound healing should create a better and comprehensive understanding of the NPWT effects in this field.

NCT ID: NCT02466594 Completed - Microcirculation Clinical Trials

Impact of Active Thermoregulation on the Microcirculation of Free Flaps

Start date: November 2013
Phase: N/A
Study type: Interventional

This study evaluates the impact of active thermoregulation on free flap microcirculation following free flap transfer. Thermoregulation is performed by passive warming, active warming (water circulation based device) and active cooling. Changes in microcirculation are assessed using combined laser Doppler flowmetry and remission spectroscopy.

NCT ID: NCT01418118 Completed - Clinical trials for Head and Neck Cancer

Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

Free4Flow
Start date: October 2008
Phase: Phase 4
Study type: Interventional

Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck. Following this type of surgery, patients often need medication to maintain their blood pressure in the intensive care unit. The effect of these drugs on the transplanted tissues is unknown. This study investigates the effects of four commonly used drugs on free flap perfusion.