Frailty Clinical Trial
Official title:
Loss of Independence (LOI) - a Rapid Alternative to Frailty Screening in a Swedish Emergency Department Setting
Verified date | May 2022 |
Source | University Hospital, Linkoeping |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This prospective observational study will investigate the correlation of a surrogate marker of frailty in relation to serious outcomes. Serious outcomes are defined as: mortality within 30 days, admission to hospital, length of stay in the Emergency Department (ED), in-hospital Length of Stay and revisits to the ED. The exposure, frailty, will be assessed according to Loss of Independence (LOI) a possible low-cost quick tool to identify frailty in patients. The study population will be ED patients, >65 years of age in a Swedish regional health care system (Region Östergötland, Sweden), comprising three EDs in Linköping, Norrköping and Motala. The outcomes will be compared according to the degree of frailty and censored over 7, 30 and 90 days.
Status | Completed |
Enrollment | 1800 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years and older |
Eligibility | Inclusion Criteria: - = 65 years - able to answer questions to estimate frailty - or have a proxy to answer questions Exclusion Criteria: - <65 years - unable to answer questions to estimate frailty |
Country | Name | City | State |
---|---|---|---|
Sweden | University Hospital Linköping | Linköping | Östergötland |
Sweden | Medicinska Specialist Kliniken i Motala | Motala | Östergötland |
Sweden | Vrinnevisjukhuset i Norrköping | Norrköping | Östergötland |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Linkoeping |
Sweden,
Berian JR, Mohanty S, Ko CY, Rosenthal RA, Robinson TN. Association of Loss of Independence With Readmission and Death After Discharge in Older Patients After Surgical Procedures. JAMA Surg. 2016 Sep 21;151(9):e161689. doi: 10.1001/jamasurg.2016.1689. Epub 2016 Sep 21. — View Citation
Brabrand M, Folkestad L, Clausen NG, Knudsen T, Hallas J. Risk scoring systems for adults admitted to the emergency department: a systematic review. Scand J Trauma Resusc Emerg Med. 2010 Feb 11;18:8. doi: 10.1186/1757-7241-18-8. Review. — View Citation
Brabrand M, Lassen AT, Knudsen T, Hallas J. Seven-day mortality can be predicted in medical patients by blood pressure, age, respiratory rate, loss of independence, and peripheral oxygen saturation (the PARIS score): a prospective cohort study with external validation. PLoS One. 2015 Apr 13;10(4):e0122480. doi: 10.1371/journal.pone.0122480. eCollection 2015. — View Citation
Kellett J, Deane B, Gleeson M. Derivation and validation of a score based on Hypotension, Oxygen saturation, low Temperature, ECG changes and Loss of independence (HOTEL) that predicts early mortality between 15 min and 24 h after admission to an acute medical unit. Resuscitation. 2008 Jul;78(1):52-8. doi: 10.1016/j.resuscitation.2008.02.011. Epub 2008 Apr 10. — View Citation
Kellett J, Deane B. The Simple Clinical Score predicts mortality for 30 days after admission to an acute medical unit. QJM. 2006 Nov;99(11):771-81. Epub 2006 Oct 17. — View Citation
Rylance J, Baker T, Mushi E, Mashaga D. Use of an early warning score and ability to walk predicts mortality in medical patients admitted to hospitals in Tanzania. Trans R Soc Trop Med Hyg. 2009 Aug;103(8):790-4. doi: 10.1016/j.trstmh.2009.05.004. Epub 2009 Jun 21. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mortality in 30 Days | Investigate level of mortality in cohort at 30 days | All cause mortality up to 30 days from index visit | |
Secondary | Mortality in 7 and 90 days | Investigate level of mortality in cohort at 7 and 90 days | All cause mortality up to 90 days from index visit | |
Secondary | Admission to hospital | Investigate level of all cause admissions in cohort | Hospital admission on index visit, censored at 90 days | |
Secondary | ED length of stay | Investigate length of stay at ED | Length of stay at ED, censored at 4 days | |
Secondary | In-hospital length of stay | Investigate in-hospital length of stay | In-hospital length of stay from index visit, censored at 90 days | |
Secondary | Revisits to the ED | Number of newly registered visits to the ED after index visit | Number of newly registered visits to the ED after index visit, censored at 90 days | |
Secondary | Fall prevalence after index visit | Falls that resulted in further health care contacts | Falls that resulted in further health care contacts after index visit, censored at 90 days | |
Secondary | Alterations in medication during the visit | Alterations in medication during the ED visit and during the follow-up period(based on codes for Anatomical, Therapeutic, Chemical classification (ATC-code) | Alterations in medication during the ED visit and during the follow-up period, censored at 90 days |
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