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Clinical Trial Details — Status: Terminated

Administrative data

NCT number NCT04055896
Other study ID # 2727 (Amendment)
Secondary ID
Status Terminated
Phase N/A
First received
Last updated
Start date October 15, 2019
Est. completion date March 30, 2021

Study information

Verified date June 2021
Source McMaster University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Medication side effects and interactions between medications are very common in older adults and are related to negative health outcomes. In this study, the investigators will test a new process aimed at reducing unnecessary medication use and drug side effects in seniors using the best medical evidence and patient preferences for treatment. This study will assess how feasible the implementation of this intervention is within a long-term care facility as well as if it is possible. Participants in two long-term care facilities will participate in this study. Measures will include feasibility outcomes regarding the logistics of the intervention as well as patients outcomes (falls, hospitalizations, and medications) collected before and after implementation. This trial will be a randomized control trial with an adaptive trial design.


Description:

There are substantial associations between polypharmacy and reduced function from older adults and this is likely to be important in frail older adults both in long term care and in the community. The reversibility of drug-induced mobility impairment is unclear therefore the investigators plan to investigate signals of any impact of reducing polypharmacy on mobility. The investigators chose the long-term care setting given the presence of complete medication administration records and this patient population's high prevalence of polypharmacy and risk of adverse drug events. TaperMD is an electronic tool for systematic medication reduction that incorporates patient priorities, electronic screening for potentially harmful medicines,supporting evidence tools and a monitoring pathway to support medication reduction. This study will examine the feasibility of this tool in a long-term care setting as well as examine. Participants in two long-term care facilities will participate in this study. Measures will include feasibility outcomes regarding the logistics of the intervention as well as patients outcomes (falls, hospitalizations, and medications) collected before and after implementation. The study will be an adaptive trial design with two phases. Phase 1 will be an internal pilot. This will allow the investigators to re-evaluate and modify outcome measures and processes as necessary. Phase 2 of this trial will allow for continuation after adjustments to the process or design has been made in a larger randomized controlled trial.


Recruitment information / eligibility

Status Terminated
Enrollment 15
Est. completion date March 30, 2021
Est. primary completion date March 30, 2021
Accepts healthy volunteers No
Gender All
Age group 70 Years and older
Eligibility Inclusion Criteria: - residing in 2 long-term care facilities in Brampton, ON - on 5 or more long-term medications - 70 years of age or older - adequate English language Exclusion Criteria: - terminal illness or other circumstance precluding 6 month study period - recent (within 12 months) comprehensive medication review

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Medication Reduction
Systematic approach to reduction in polypharmacy

Locations

Country Name City State
Canada Holland Christian Homes - Faith Manor Brampton Ontario
Canada Holland Christian Homes - Grace Manor Brampton Ontario

Sponsors (3)

Lead Sponsor Collaborator
McMaster University Canadian Frailty Network, Labarge Optimal Aging

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Other Loved one's perspective of deprescribing Perspectives from focus groups 6 months
Primary Successful Discontinuation (Difference in mean number of medications; reduction in dose) Difference in mean number of medications; number of medications reduced in dose 6 months
Secondary Difference in level of cognition The Mini Mental Status Examination Baseline, 6 months
Secondary Difference in level of quality of life EuroQol five dimensions questionnaire (EQ5D-5L) will measure quality of life. Scores range from 0 (low quality of life) to 1 (high quality of life). Baseline, 6 months
Secondary Difference in number of falls Total number of falls resulting in medication consultation or treatment recorded in hospital admission and primary care records, and by patient Baseline, 6 months
Secondary Difference in level of sleep The sleep question on the 15-Dimensional (15-D) scale will be used. Scores range from 1 (no sleep problems) to 5 (severe sleep problems). Baseline, 6 months
Secondary Changes in medication side effects and symptoms (adverse) Patient self-report of appearance (new or worsening) of side effects associated with medications 1-week, 3 months, 6 months
Secondary Changes in medication side effects and symptoms (positive) Patient self-report of disappearance (improvement or disappearance) of side effects associated with medications 1-week, 3 months, 6 months
Secondary Difference in number of serious adverse events Any event that requires in-patient hospitalization or prolongation of existing hospitalization, causes congenital malformation, results in persistent or significant disability or incapacity, is life-threatening or results in death (Health Canada (2011) Guidance Document for Industry - Reporting Adverse Reactions to Marketed Health Products) 1-week, 3 months, 6 months
Secondary Difference in level of physical functioning capacity and ability Time on the timed-up-and-go test Baseline, 6 months
Secondary Difference in level of performance of activities of daily living Barthel Index will be used to measure performance of activities of daily living. Ten activities are scored in terms of level of independence or assistance, with higher scores reflecting higher level of independent performance. Baseline, 6 months
Secondary Difference in level of frailty The total score on the Edmonton Frail Scale will be used to measure frailty. The scale included 11 items, with scores ranging from 0 (not frail) to 17 (severe frailty). Baseline, 6 months
Secondary Difference in level of healthcare utilization use (hospitalizations) Number of hospitalizations Baseline, 6 months
Secondary Difference in level of healthcare utilization use (emergency department visits) Number of emergency department visits Baseline, 6 months
Secondary Difference in level of healthcare utilization use (physician visits) Number of physician visits Baseline, 6 months
Secondary Enrollment rate Number of participants that enroll in study relative to number of participant invited to participant 6 months
Secondary Completion rate Number of participants that complete 6-month collection relative to number of participants enrolled 6 months
Secondary Time to complete measures Average duration of data collection appointments Baseline, 6 months
Secondary Difference in level of mood The total score on the Geriatric Depression Scale (Short Form) will be used to measure mood. The scale includes 15 yes/no items and score range from 0 to 15, with high scores indicating depression. Baseline, 6 months
Secondary Difference in level of concern over falling The score on the Falls Efficacy Scale-International (Short Version) will be used to measure falling-related concerns. The scale includes 7 items, with scores ranging from 7 (no concern) to 28 (severe concern of falling) Baseline, 6 months
Secondary Difference in level of pain The Brief Pain Inventory (short form) will be used to measure pain severity (mean of 4 items, rated 0-10) and pain interference (mean of 7 items, rated 0-10). Higher scores represent higher pain severity and interference. Baseline, 6 months
Secondary Difference in level of incontinence Frequency of incontinence as recorded in patient electronic medical record Baseline, 6 months
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