Fractured Neck of Femur Clinical Trial
Official title:
Effects of a Single Dose of Dexamethasone in Patients Undergoing Operative Fixation of Proximal Femur Fracture
Fracture neck of femur is a common cause of hospital admission in the elderly and requires
operative fixation.
Dexamethasone has the potential of inhibiting cortisol secretion. In addition, preoperative
glucocorticoids improve analgesia and decrease opioid consumption with reduction in
associated side effects in a variety of clinical settings.
The investigators hypothesis was that a single dose of preoperative dexamethasone enhance
postoperative analgesia and attenuates the inflammatory response in patients undergoing
operative fixation of fractured neck of femur, in a prospective, randomized, placebo
controled trial.
Having obtained ethical approval and written informed consent from each, 40 patients
scheduled to undergo operative fixation of fractured neck of femur will be randomized using
sealed envelopes to two groups.
Patients in the Dexamethasone group receive a single dose of 0.1 mg/kg dexamethasone iv.
preoperative, patients in the Placebo group receive the same amount of Normal Saline. The
anaesthetic technique is standardized, salive samples, blood samples are taken and pain
scores are measured on a visual analog scale postoperatively at several timepoints.
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