Food (Shrimp) Allergy Clinical Trial
Official title:
The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis
The purpose of this study was to investigate the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis.
The diagnosis of anaphylaxis is based primarily on the clinical history. In some
circumstances, inability to confirm the clinical diagnosis such as present with unusual
manifestation, or when skin signs are absent likely contributes to underrecognition and
undertreatment of the disease.
Currently, products of mast cell activation (histamine and total tryptase) can be measure in
clinical laboratories as markers of acute anaphylaxis events, however these tests have
clinically relevant limitations.
Therefore, development of laboratory tests with improved sensitivity and specificity that
will support the clinical diagnosis of anaphylaxis are needed.
In addition, shrimp is the major cause of seafood anaphylaxis among Thai children.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic