The Associations Between Gut Length, Gut Microbiota & Food Assimilation

Status Not yet recruiting

Clinical Trial Summary

The purpose of this observational study is to explore the relationships between gut length, the microbiota and food energy assimilation rates in humans.

Clinical Trial Description

The focus of this work is to characterize the relationship between gut length, gut microbiota and food energy assimilation rate in healthy individuals. The gut will be scanned using Magnetic Resonance Imaging (MRI) to calculate gut length. To obtain clearer images, volunteers will be asked to drink 1/1.5 sachet of He Shuang (polyethylene glycol electrolyte powder, molecular weight of 4000) and injected Raceanisodamine Hydrochloride Injection with 10 mg by intramuscular. Volunteers will be asked to drink He Shuang, which dissolved in 1/1.5L of water for the purpose of filling the intestines. As a contrast to improve imaging during scanning. Volunteers will be given the experimental meal, which providing enough energy for volunteers to eat as much as they want. Feces and urine will be collected to calculate the assimilation rate. To more accurately label the food, edible polyethylene glycol with a molecular weight of 3350(PEG3350) is used. Provides 1.5g of PEG3350 per day, to be used with meals. PEG3350 reaches a steady state in the intestinal tract for 3 days. Food will be provided for seven days during the test period, the first three days are aimed at stabilizing the PEG3350 in the intestine, and the samples to be counted are mainly collected in the last four days. Food assimilation rate and metabolizable energy will be calculated for the 4-day. The gut microbiota will be analyzed by metagenomics and metabolomics. This study combines metabolomics analysis techniques with imaging and physiological measurements to focus on the potential relationship between gut length and food absorption rates. Researchers anticipate recruiting up to 100 healthy volunteers (body mass index ≥ 18.5). ;

Study Design

Related Conditions & MeSH terms

Food Preferences
Metabolic Syndrome
Metabolic Syndrome, Protection Against

Clinical Trial Details

NCT number	NCT06377956
Study type	Observational
Source	Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
Contact	John R Speakman, PhD
Phone	15810868669
Email	j.speakman@abdn.ac.uk
Status	Not yet recruiting
Phase
Start date	May 15, 2024
Completion date	June 1, 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03003923` - Promoting Vegetable Intake in Preschool Aged Children	N/A
Completed	`NCT03113474` - Profiling the Endocannabinoid Response to Hedonic Eating	N/A
Recruiting	`NCT04662606` - Neurofunctional Correlates of Intentional Actions Towards Food Stimuli	N/A
Recruiting	`NCT06015490` - The Impact of the Physiological Response to Sugar on Brain Activity and Behavior	N/A
Recruiting	`NCT05652842` - Assessing the Impact of Rotational and Shift Work on Sleep, Activity, Energy Balance, and Food Choice in Adults
Completed	`NCT05079477` - Online Study of the Effects of Sugary Drink Warning Labels on Consumption	N/A
Recruiting	`NCT05977348` - Increasing Food Literacy in Preschoolers to Reduce Obesity Risk	N/A
Completed	`NCT04544332` - The GAIN Study: Understanding What Helps Children Learn to Like and Eat New Foods
Completed	`NCT04497974` - Sweet Tooth: Nature or Nurture? Role of Long-term Dietary Sweetness Exposure on Sweetness Preferences	N/A
Completed	`NCT03400566` - Effects of Experiential Learning on Vegetable Intake in Preschool Children	N/A
Active, not recruiting	`NCT04262102` - The Dastatuz Project	N/A
Completed	`NCT05592340` - Restaurant Menu Carbon Footprint Labeling	N/A
Recruiting	`NCT02005003` - Cognitive and Metabolic Effects of a Probiotic Supplement	N/A
Completed	`NCT05432271` - Online Food and Beverage Labels and Vending Machine Selections	N/A
Active, not recruiting	`NCT04788836` - How Altered Gut-Brain-Axis Influences Food Choices: Part 2 (BrainFood)
Completed	`NCT05175391` - Improving Protein Intake in Older Adults	N/A
Not yet recruiting	`NCT06324630` - Implementation of Innovative Food Prescription Programs in Older Adults	N/A
Recruiting	`NCT02931812` - Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation
Completed	`NCT02457234` - Influence of Cultural Immersion on Willingness to Try Fruits and Vegetables Among Children in Guam: the Traditions Study	N/A
Recruiting	`NCT06432517` - Sources and Mechanisms of Energy Compensation	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Associations Between Gut Length, Gut Microbiota and Food Assimilation

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms