Specific Oral Tolerance Induction to Cow's Milk Allergy

Status Completed

Clinical Trial Summary

Background: Limited published evidence shows specific oral tolerance induction (SOTI) to be a potential intervention option for cow's milk proteins (CMPs) allergy. Our hypothesis is that SOTI should be started early in order to improve its efficacy and prevent CMPs sensitization from evolving towards persistent allergy. The aim of this study was to evaluate the safety and efficacy of SOTI in 2-year-old children with cow's milk allergy, as a treatment alternative to elimination diet.

Methods: A total of 60 children between 24-36 months of age with IgE-mediated allergy to CMPs were included in this multicenter study and were randomly divided into two different groups. Thirty children (group A: treatment group) began SOTI immediately, whereas the remaining 30 (group B: control group) were kept on a milk-free diet and followed-up on for one year.

Clinical Trial Description

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Study Design

N/A

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01199484
Study type	Interventional
Source	Valencia University General Hospital
Contact
Status	Completed
Phase	N/A

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