Inhibition of Anaphylaxis by Ibrutinib

Status Completed

Clinical Trial Summary

This is a phase II open label study on the use of Ibrutinib on the inhibition of food-induced anaphylaxis in adults with food allergy. Ibrutinib (brand name Imbruvica) is currently FDA approved for the treatment of mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenstrom's macroglobulineia (WM). We propose to administer this approved drug to adults with food allergy to inhibit food allergy responses.

Clinical Trial Description

This is open-label study designed to determine the fewest doses and shortest length of time, from two days to up to 7 days, needed for ibrutinib to fully inhibit tests for food allergy, and to determine the length of persistence of efficacy after the drug is stopped. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03149315
Study type	Interventional
Source	Ann & Robert H Lurie Children's Hospital of Chicago
Contact
Status	Completed
Phase	Phase 2
Start date	April 10, 2017
Completion date	November 14, 2018

View Details

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