Follicular Lymphoma Clinical Trial
Official title:
Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma
To learn if obinutuzumab in combination with CC-99282 can help to control previously untreated, high tumor burden FL
Objectives: Primary Objectives: • To determine the efficacy of obinutuzumab in combination with CC-99282 as determined by complete response (CR) rate after six cycles of combination treatment for patients with previously untreated, high tumor burden follicular lymphoma (FL). Secondary Objectives: • To determine best overall response rate (ORR), duration of response (DOR), time to next treatment, CR rate at 30 months (CR30), progression-free survival (PFS), overall survival (OS), and evaluation of safety of obinutuzumab and CC-99282 as treatment for previously untreated patients with FL. Exploratory Objective: - To determine the biomarkers that correlates with response and mechanisms of resistance to obinutuzumab and CC-99282 in FL. - To determine the quality of life in patients with FL receiving obinutuzumab and CC-99282 ;
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