Folic Acid Deficiency Clinical Trial
Official title:
The Effect of Folic Acid Concentration and Folic Acid Supplementation on Warfarin Pharmacokinetic and Warfarin Dose Requirement at Steady State.
Folic acid supplementation has been shown previously to be associated with enhanced
formation of p-HPPH from phenytoin, a metabolic pathway which is predominantly mediated
through the activity of CYP2C9.
The metabolism of S warfarin, the more active enantiomer of warfarin, is also mediated
predominantly through the activity of CYP2C9.
The purpose of the present study was to examine the relationship between folic acid
concentration and warfarin pharmacokinetic as well as warfarin dose requirement among
patients treated by warfarin. In addition the effect of folic acid supplementation (5 mg/d)
for 3 weeks on warfarin pharmacokinetic and warfarin dose requirement will be evaluated in
the second part of the study.
n/a
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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