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Cortical Excitability Assessment Using Paired Pulses — PP  

Focal Epilepsy Clinical Trial

Official title:
Cortical Excitability Assessment of Pharmacoresistant Focal Epilepsy Using Direct Electrical Stimulation During Stereo-electroencephalography

Clinical Trial Summary

The identification of the epileptogenic zone (EZ) during pharmacoresistant focal epilepsy presurgical assessment frequently requires intracranial recordings like stereo-electroencephalography (SEEG). Cortical direct electrical stimulation (DES) is commonly used during SEEG for functional mapping or to induce seizure.

However, the recording of seizures is sometimes insufficient to circumscribe the EZ and development of new biomarkers is necessary.

The cortex within the EZ is thought to be hyperexcitable. The "paired pulses" paradigm, using transcranial magnetic stimulation (TMS), allows determining the hemispheric cortical excitability level. The investigators hypothesize that paired pulses DES during SEEG could provide useful information for EZ identification.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02245061
Study type Interventional
Source Hospices Civils de Lyon
Contact Sylvain RHEIMS, MD
Phone 4 17 30 60 64
Email sylvain.rheims@univ-lyon1.fr
Status Recruiting
Phase N/A
Start date September 9, 2014
Completion date September 30, 2021
View Details
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