Healthy Volunteers Clinical Trial
Official title:
Depotentiation in Focal Hand Dystonia Patients
Background:
- Focal hand dystonia (FHD) causes muscles to contract, leading to abnormal movements or
postures. Musicians, writers, and athletes often get it. Researchers want to study how
patients with this condition learn, a process of the brain that depends on a property called
plasticity.
Objective:
- To study brain plasticity in people with FHD.
Eligibility:
- Right-handed adults 18 years and older with FHD.
- Healthy, right-handed adult volunteers.
Design:
- Participants will be screened with medical history, physical exam, pregnancy test, and
questionnaire about their right-handedness.
- Participants will have 2 study visits on 2 different days.
- Participants will sit in a chair and have up to 30 Transcranial Magnetic Stimulation
(TMS) pulses on the left side of the head. A brief electrical current passes through a
wire coil on the scalp. They will hear a click and may feel a pulling on the skin or
muscle twitches. They may have to keep their eyes open and remain alert, tense certain
muscles, or perform simple finger movements.
- Forty more pulses, with 10 seconds between, will be given on the left side of the head.
Some will be small, some big.
- Researchers will measure muscle response through small electrodes taped to the right
hand.
- A cloth cap will be put on the participant s head. Researchers will write on tape on the
cap.
- Participants will have the r-PAS. An electrical stimulator will be placed on the nerve
at the right wrist. Repeated magnetic pulses will be delivered in trains or short bursts
together with electrical stimulation of nerve. Participants will receive up to 840
pulses.
- Participants will be contacted after a few days for a follow-up check.
Objectives:
Primary objectives:
To explore the proper parameters creating a long-term depression (LTD)-like effect and
depotentiation (DePo) by using rapid paired associative stimulation (rPAS) in focal hand
dystonia (FHD) patients
Sample Size and Population:
We plan to recruit 28 healthy volunteers (HVs) and 28 FHD patients from the Movement
Disorders and Botulinum Toxin (BoNT) clinics of HMCS.
Design:
Phase 1 deals with HVs while phase 2 deals with FHD patients. We will complete phase 1 before
starting phase 2. Each phase is composed of 2 experiments. In phase 1, experiments 1 and 2
will create the LTD-like effect and DePo in HVs and in phase 2, experiments 3 and 4 will
elicit the LTD-like effect and DePo in FHD patients. We will use regression analysis to show
that the motor evoked potential (MEP) amplitude declines after eliciting the LTD-like effect
and DePo.
Outcome measurements:
Primary outcome:
Determining the parameters for creating the LTD-like effect and DePo in HVs and FHD using
rPAS
Secondary outcome:
Measuring the percent change of the MEP amplitude after applying the proper stimulus
parameters causing an LTD-like effect and DePo in both HVs and FHD.
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