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Neural Correlates of tVNS

fMRI Clinical Trial

Official title:
Functional Neural Correlates of Transcutaneous Vagal Nerve Stimulation: Effects of Anatomical Site and Waveform Parameters - An Exploratory High Resolution fMRI Study in Healthy Volunteers

Clinical Trial Summary

Transcutaneous vagal nerve stimulation (tVNS) has been applied to a number of disease areas including visceral pain, depression, cluster headache and Alzheimer's disease. However, there is marked heterogeneity in these studies pertaining to i) the anatomical site of stimulation (neck, inner concha or tragus of ear), and ii) the waveform parameters of the stimulating impulse. This exploratory cross-sectional study will address these knowledge gaps by comparative functional neuroimaging of the neural correlates of tVNS with disparate anatomical sites and electrical waveform characteristics during rest in healthy participants.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • fMRI
  • Nucleus of the Solitary Tract (NTS)
  • Transcutaneous Vagal Nerve Stimulation (tVNS)
Clinical Trial Details
NCT number NCT04810234
Study type Observational
Source Maastricht University Medical Center
Contact Abraham Beckers, MD
Phone +31433881844
Email ab.beckers@maastrichtuniversity.nl
Status Recruiting
Phase
Start date November 1, 2020
Completion date June 1, 2021
View Details
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