Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery

Fluid Therapy Clinical Trial

— fluidresponse  

Official title:

Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06249568
• Other study ID #: E2-23-3460
• Status: Recruiting
• Start date: June 1, 2023
• Est. completion date: February 20, 2024

Study information

• Verified date: January 2024
• Source: Ankara City Hospital Bilkent
• Contact: meltem sakman yilmaz
• Phone: +90 505 922 1049
• Email: meltemsakmann[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Assuming that the basic reliability of dynamic indices will increase with the application of functional hemodynamic tests after sternotomy and protective lung ventilation in patients undergoing elective coronary artery bypass surgery, it is useful to predict fluid responsiveness after sternotomy in coronary artery bypass surgery patients ventilated with 6 ml/kg PBW (ideal body weight). We aimed to reveal the sensitivity and specificity of PPV and SVV changes by applying a lung opening maneuver.

Description:

In order to evaluate the fluid deficit in patients undergoing coronary artery bypass surgery, researchers will measure stroke volume index, cardiac index and mean arterial pressure while the patients are in the lima position. Then researchers will perform a lung opening maneuver (30mmHg for 30 seconds) and measure again. researchers will measure again after the values return to normal. researchers will give patients balanced fluid at 3ml/kg and record their values. Can researchers predict fluid response with lung opening maneuver?

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 45
• Est. completion date: February 20, 2024
• Est. primary completion date: February 2, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

• Inclusion Criteria:
• 1-ASA2-3 patients between the ages of 18-80 who will undergo elective coronary bypass surgery under general anesthesia
• Exclusion Criteria:
• 1. Be younger than 18 years old, be over 80 years old
• 2. Patients with an ASA score greater than 3
• 3. EF<40%
• 4. Those with contraindications to anesthetic drugs
• 5. Patients with BMI>30
• 6. Patients who did not want to participate in the study
• 7. Right ventricular dysfunction
• 8. COPD(Chronic obstructive pulmonary disease)
• 9. Bullous lung disease
• 10. Moderate to severe PHT
• 11. Severe kidney or liver disease
• 12. Patients with hemodynamic instability in the perioperative period
• 13. Pregnancy

Related Conditions & MeSH terms

• Coronary Artery Bypass Surgery Patients
• Fluid Therapy

Locations

Country	Name	City	State
Turkey	Ankara Bilkent Sehir Hastanesi	Ankara

Sponsors (1)

Lead Sponsor	Collaborator
Ankara City Hospital Bilkent

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Determination of fluid responsiveness in patients undergoing coronary arter bypass surgery.	: Demonstration of fluid responsiveness in patients who will undergo coronary artery bypass surgery will prevent unnecessary fluid administration in case of hemodynamic disturbance, and medical treatments and interventions can be performed in a timely and targeted manner. Researchers will perform a recruitment maneuver on the patients and record mean arterial pressure and stroke volume index.; Researchers will perform a recruitment maneuver on the patients and record mean arterial pressure and stroke volume index.; Afterwards, researchers will give 3ml/cc balanced fluid to the patient and record the change in mean arterial pressure and stroke volume index.	from start to 4 months