TEE as a Guide for Fluid Optimization in Major Abdominal Oncosurgery — VTI SVV  

Fluid Therapy Clinical Trial

Official title: Transesophageal Echocardiography as a Guide for Fluid Optimization in Major Abdominal Oncosurgery

Status Completed

Clinical Trial Summary

Transesophageal echocardiography (TEE) as guide for tailoring perioperative fluid therapy to achieve individualized hemodynamic endpoint, target hemodynamic goals of stroke volume index (SVI) greater than 35 mL/m2 and cardiac index greater than 2.5 L/min/m2 and tissue oxygen delivery.

Lactate levels as a surrogate indicator of organ perfusion as measured by arterial blood gas analysis intraoperatively, after 12 hours and 48 hrs postoperatively

Clinical Trial Description

TEE as guide for tailoring perioperative fluid therapy to achieve target hemodynamic goals of stroke volume index (SVI) greater than 35 mL/m2 and cardiac index greater than 2.5 L/min/m2 and tissue oxygen delivery.

GDT (goal directed therapy): continuous infusion of crystalloids 2 mL/kg/h.

If (velocity time integral) VTI <20, 250 mL colloid bolus administered. Dose repeated every 10 min until goal of VTI >20 met. Norepinephrine titrated to maintain MAP(mean arterial pressure) > 65 mm Hg. Blood transfused for haemoglobin <8 g Lactate levels as a surrogate indicator of organ perfusion as measured by arterial blood gas analysis at time of incision intraoperatively and after 12 hours and 48 hrs. The incidence of postoperative complications, morbidity, mortality, duration of mechanical ventilation and ICU stay. ;

Related Conditions & MeSH terms

• Fluid Therapy

• NCT number: NCT03140540
• Study type: Interventional
• Source: Rajiv Gandhi Cancer Institute & Research Center, India
• Status: Completed
• Phase: N/A
• Start date: February 16, 2019
• Completion date: February 27, 2020