Fluid Overload Clinical Trial
— ULRICAOfficial title:
The Effect of Hemodialysis on proBNP
Patients performing chronic hemodialysis (HD) retain more or less water between dialyses. The water is removed by ultrafiltration and usually during the cleansing of waste products - the HD. The length of HD is usually the same as the time of fluid removal while sometimes this may differ. There is no clear guideline. In previous research the investigator noted that the heart releases more NT-pro-BNP during HD in numerous of the patients. The present study aims to clarify if the speed of fluid removal during HD is a factor that may alter the release of cardiac markers during HD. If so the recommendations for the prescription of HD can be updated.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | April 2024 |
Est. primary completion date | March 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Adult HD patients with an intra-dialytic weight gain (IDWG) =2.5% of target weight over the long interval (3 days) prior to inclusion. - Patients need to be able to understand the study information - Patients need to be able to give consent. Exclusion Criteria: - Active systemic inflammatory state such as extensive malignancy or acute septic infection. - Uncontrolled hyperphosphatemia decided by the local routine of the physician (due to somewhat decreased efficacy of the low flux filter to eliminate phosphate) |
Country | Name | City | State |
---|---|---|---|
Sweden | Region Vasterbotten, Norrlands Universitetssjukhus, Dialysen | Umea |
Lead Sponsor | Collaborator |
---|---|
Umeå University |
Sweden,
Goto J, Forsberg U, Jonsson P, Matsuda K, Nilsson B, Nilsson Ekdahl K, Henein MY, Stegmayr BG. Interdialytic weight gain of less than 2.5% seems to limit cardiac damage during hemodialysis. Int J Artif Organs. 2021 Aug;44(8):539-550. doi: 10.1177/03913988 — View Citation
Goto J, Ott M, Stegmayr B. Myocardial markers are highly altered by higher rates of fluid removal during hemodialysis. Hemodial Int. 2023 Oct 24. doi: 10.1111/hdi.13124. Online ahead of print. — View Citation
Schneditz D, Putz-Bankuti C, Ribitsch W, Schilcher G. Correction of plasma concentrations for effects of hemoconcentration or hemodilution. ASAIO J. 2012 Mar-Apr;58(2):160-2. doi: 10.1097/MAT.0b013e318243660f. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in NT-pro-BNP (proBNP) | The investigation focuses on the marker for cardiac strain pro-BNP (ng/L). Question: Does the heart get less release of markers for cardiac strain upon a slower speed of fluid removal. | Per patient: two dialyses within 8 days; Study period:1 year | |
Secondary | Change in troponin T | The investigation includes the markers for cardiac strain troponin T (ng/L). Question: Does the heart get less release of markers for cardiac strain upon a slower speed of fluid removal. | Per patient: two dialyses within 8 days; Study period:1 year | |
Secondary | Adverse events | The two study dialysis protocols will be analyzed for eventual adverse events. | Per patient: two dialyses within 8 days; Study period:1 year |
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