Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04928040
Other study ID # 2020/436
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date June 22, 2021
Est. completion date January 16, 2022

Study information

Verified date January 2022
Source Ondokuz Mayis University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Fluid challenge is frequently used in fluid management of critically ill patients. Assessing whether there is a preload reserve that can be used to increase the stroke volume by delivering a small amount of fluid in a short period of time. Optimization of fluid therapy is very important in intensive care patients. Inappropriate fluid therapy can cause significant morbidity and even mortality. Increased intracranial pressure is one of these important complications. In the present study, we planned to evaluate the effect of a fluid challenge on intracranial pressure by measuring the optic nerve sheath diameter (ONSD).


Description:

The fluid challenge is a simple volume resuscitation evaluation method that provides an indication of the patient's likelihood of benefiting from an increase in the intravenous fluid volume. Both the fluid challenge and fluid responsiveness are evaluated by interpreting the change in hemodynamic parameters after 500 mL of crystalloid (or 250 mL of colloid) solution is infused over 10-15 min. This is done in an attempt to regulate the fluid therapy of hemodynamically unstable patients in order to prevent fluid overload. In the present study, we aim to investigate the effect of the fluid challenge maneuver on intracranial pressure in ICU patients with hemodynamic instability through measuring the optic nerve sheath diameter by ultrasonography. Patients in the intensive care unit undergoing a fluid challenge were included in this prospective observational study. A fluid challenge is defined as a 500 mL crystalloid infusion administered over 10 min, and fluid responsiveness is defined as a subsequent increase in stroke volume of at least 15%. The ONSD and hemodynamic variables will be measured by ultrasonography before (T0), at the end (T1), and 30 min after the fluid challenge (T2). The primary outcome of the study is the change in intracranial pressure associated with the fluid challenge, and the secondary outcome is the relationship between fluid responsiveness and the change in ONSD.


Recruitment information / eligibility

Status Completed
Enrollment 60
Est. completion date January 16, 2022
Est. primary completion date January 1, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: 1. Patients with no known intracranial pathology. 2. Patients with systolic blood pressure < 90 mmHg 3. Patients with mean blood pressure < 65 mmHg 4. Patients with tachycardia (heart rate 100 beats/min) 5. Patients with mottled skin, oliguria (diuresis of less than 20 ml/hr or 0.5 ml/kg/hr for two hours), and acute renal failure. 6. Patients with arterial lactate concentration > 2 mmol/L Exclusion Criteria: 1. Patients with known intracranial hypertension 2. Patients in the early postpartum period 3. Patients with severe mitral or aortic regurgitation 4. Patients with cardiac arrhythmia 5. Patients unable to be evaluated due to poor echogenicity

Study Design


Intervention

Diagnostic Test:
Measurement of optic nerve sheath diameter
The fluid challenge effects of optic nerve sheath diameter

Locations

Country Name City State
Turkey Ondokuz Mayis Universitesi Atakent Samsun

Sponsors (1)

Lead Sponsor Collaborator
Ondokuz Mayis University

Country where clinical trial is conducted

Turkey, 

References & Publications (4)

Cecconi M, Parsons AK, Rhodes A. What is a fluid challenge? Curr Opin Crit Care. 2011 Jun;17(3):290-5. doi: 10.1097/MCC.0b013e32834699cd. Review. — View Citation

Hoste EA, Maitland K, Brudney CS, Mehta R, Vincent JL, Yates D, Kellum JA, Mythen MG, Shaw AD; ADQI XII Investigators Group. Four phases of intravenous fluid therapy: a conceptual model. Br J Anaesth. 2014 Nov;113(5):740-7. doi: 10.1093/bja/aeu300. Epub 2014 Sep 9. Review. — View Citation

McGuire G, Crossley D, Richards J, Wong D. Effects of varying levels of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure. Crit Care Med. 1997 Jun;25(6):1059-62. — View Citation

Rajajee V, Vanaman M, Fletcher JJ, Jacobs TL. Optic nerve ultrasound for the detection of raised intracranial pressure. Neurocrit Care. 2011 Dec;15(3):506-15. doi: 10.1007/s12028-011-9606-8. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary The change in intracranial pressure associated with the fluid challenge The change in intracranial pressure according to the optic nerve sheath diameter measurements. Before, at the end, and 30 min after the fluid challenge.
Secondary The relationship between fluid responsiveness and the change in optic nerve sheath diameter The fluid responsiveness associated with the change in optic nerve sheath diameter measurements Before, at the end, and 30 min after the fluid challenge.
See also
  Status Clinical Trial Phase
Not yet recruiting NCT01941472 - Transcutaneous pO2, Transcutaneous pCO2 and Central Venous pO2 Variations to Predict Fluid Responsiveness N/A
Not yet recruiting NCT04934345 - EFFECT OF VASOPRESSORS ON FLUID CHALLENGE PERSISTENCE AN OBSERVATIONAL STUDY IN PATIENTS UNDERGOING LAPAROTOMY.
Recruiting NCT05153837 - Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers N/A
Completed NCT04535115 - Tidal Volume Challenge and Lung Recruitment Maneuver (TIDALREC): the Reliability of Pulse Pression Variation or Stroke Volume Variation on Fluid Responsiveness. N/A
Active, not recruiting NCT03874923 - Comparison of 250 ml Versus 500 ml of Fluid Challenge N/A
Recruiting NCT03397784 - IVC Variation After VT Challenge to Predict Fluid Responsiveness N/A