Fluid Challenge Clinical Trial
Official title:
Evaluation of Intracranial Pressure Change by Measuring Optic Nerve Sheath Diameter During Fluid Challenge
NCT number | NCT04928040 |
Other study ID # | 2020/436 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | June 22, 2021 |
Est. completion date | January 16, 2022 |
Verified date | January 2022 |
Source | Ondokuz Mayis University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Fluid challenge is frequently used in fluid management of critically ill patients. Assessing whether there is a preload reserve that can be used to increase the stroke volume by delivering a small amount of fluid in a short period of time. Optimization of fluid therapy is very important in intensive care patients. Inappropriate fluid therapy can cause significant morbidity and even mortality. Increased intracranial pressure is one of these important complications. In the present study, we planned to evaluate the effect of a fluid challenge on intracranial pressure by measuring the optic nerve sheath diameter (ONSD).
Status | Completed |
Enrollment | 60 |
Est. completion date | January 16, 2022 |
Est. primary completion date | January 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: 1. Patients with no known intracranial pathology. 2. Patients with systolic blood pressure < 90 mmHg 3. Patients with mean blood pressure < 65 mmHg 4. Patients with tachycardia (heart rate 100 beats/min) 5. Patients with mottled skin, oliguria (diuresis of less than 20 ml/hr or 0.5 ml/kg/hr for two hours), and acute renal failure. 6. Patients with arterial lactate concentration > 2 mmol/L Exclusion Criteria: 1. Patients with known intracranial hypertension 2. Patients in the early postpartum period 3. Patients with severe mitral or aortic regurgitation 4. Patients with cardiac arrhythmia 5. Patients unable to be evaluated due to poor echogenicity |
Country | Name | City | State |
---|---|---|---|
Turkey | Ondokuz Mayis Universitesi | Atakent | Samsun |
Lead Sponsor | Collaborator |
---|---|
Ondokuz Mayis University |
Turkey,
Cecconi M, Parsons AK, Rhodes A. What is a fluid challenge? Curr Opin Crit Care. 2011 Jun;17(3):290-5. doi: 10.1097/MCC.0b013e32834699cd. Review. — View Citation
Hoste EA, Maitland K, Brudney CS, Mehta R, Vincent JL, Yates D, Kellum JA, Mythen MG, Shaw AD; ADQI XII Investigators Group. Four phases of intravenous fluid therapy: a conceptual model. Br J Anaesth. 2014 Nov;113(5):740-7. doi: 10.1093/bja/aeu300. Epub 2014 Sep 9. Review. — View Citation
McGuire G, Crossley D, Richards J, Wong D. Effects of varying levels of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure. Crit Care Med. 1997 Jun;25(6):1059-62. — View Citation
Rajajee V, Vanaman M, Fletcher JJ, Jacobs TL. Optic nerve ultrasound for the detection of raised intracranial pressure. Neurocrit Care. 2011 Dec;15(3):506-15. doi: 10.1007/s12028-011-9606-8. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The change in intracranial pressure associated with the fluid challenge | The change in intracranial pressure according to the optic nerve sheath diameter measurements. | Before, at the end, and 30 min after the fluid challenge. | |
Secondary | The relationship between fluid responsiveness and the change in optic nerve sheath diameter | The fluid responsiveness associated with the change in optic nerve sheath diameter measurements | Before, at the end, and 30 min after the fluid challenge. |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT01941472 -
Transcutaneous pO2, Transcutaneous pCO2 and Central Venous pO2 Variations to Predict Fluid Responsiveness
|
N/A | |
Not yet recruiting |
NCT04934345 -
EFFECT OF VASOPRESSORS ON FLUID CHALLENGE PERSISTENCE AN OBSERVATIONAL STUDY IN PATIENTS UNDERGOING LAPAROTOMY.
|
||
Recruiting |
NCT05153837 -
Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers
|
N/A | |
Completed |
NCT04535115 -
Tidal Volume Challenge and Lung Recruitment Maneuver (TIDALREC): the Reliability of Pulse Pression Variation or Stroke Volume Variation on Fluid Responsiveness.
|
N/A | |
Active, not recruiting |
NCT03874923 -
Comparison of 250 ml Versus 500 ml of Fluid Challenge
|
N/A | |
Recruiting |
NCT03397784 -
IVC Variation After VT Challenge to Predict Fluid Responsiveness
|
N/A |