Flu Clinical Trial
Official title:
Sequential Quantification of Viral Load in the Upper Respiratory Tract in Adult Patients Admitted for Influenza and Treated With Olsetamivir
Seasonal influenza is a frequent disorder with high impact on morbidity and mortality and
significant burden on healthcare-related cost. In France, the 2018-2019 flu epidemic has led
to 13,100 all-cause death including 9,900 death directly related to the viral infection.
As cross-transmission of influenza is responsible for nosocomial outbreaks, preventing
transmission of infectious agents in healthcare settings is a major issue. If vaccination of
patients and healthcare givers remains cornerstone, control procedures are mandatory.
Therefore patients admitted with influenza require isolation precautions including admission
in a single room and protective measures. Based on experts advise, isolation is currently
recommended for 5 to 8 days. Duration of isolation depends on immune status and antiviral
therapy. However, during periods of epidemic, every hospital room is valuable and each
ressource has to be tightly used. Risk of contamination is related to the presence of
influenza in the upper airways. To the Promoteur 's knowledge, presence of influenza in the
upper airways has not been studied in patients receiving oseltamivir. The question is : Do
duration of isolation in patients admitted with flu decreas when they are treated with
antiviral therapy. To answer this question The Promoteur would aim to determine influenza
carriage in the upper airways in in-patients treated by olsetamivir.
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