Flu Symptom Clinical Trial
Official title:
Immune System Stimulation by Probiotic Food Supplementation: a Double-blind, Randomized, Controlled, Parallel-designed, Prospective Trial
The purpose of this study is to investigate the effects of a probiotic supplementation on
adult volunteers with having caught the common cold more than 4 times in the past year. This
study is a single center, double-blind, randomized, controlled, parallel-designed,
prospective trial. Subjects received a probiotic drink containing probiotics of
Lactobacillus paracasei (108 colony forming units (CFU)/ml), Lactobacilluscasei431®
(108CFU/ml) and Lactobacillus fermentiumPCC® (106CFU/ml) or an identical placebo without
probiotics for a 12-week study period.
The incidence of flue and cold during the study period were compared between study groups.
Blood and fecal samples were collected at baseline and at the end of the intervention. Fecal
samples were collected for the secretory immunoglobulin A (sIgA) analysis. Blood sample was
drawn for interferon γ (IFN-γ), interleukin 4 (IL-4), interleukin 10 (IL-10), immunoglobulin
A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) analysis.
n/a
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