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Clinical Trial Summary

This prospective, unicentric, open-labe phase I study is to evaluate the effects of autologous cytokine-induced killer cell immunotherapy combination with PD-1 inhibitor and chemotherapy in the first-line treatment of IIIB/IIIC/IV non-small cell lung cancer.


Clinical Trial Description

In the non-squamous NSCLC, patients received sintilimab Injection (PD-1 inhibitor) 200mg, d1; pemetrexed injection 500mg/m2, d1; carboplatin injection AUC 5, d1; CIK cells venous re-transfusion >=1x10^10, d14; Q3W, for 4 cycles. Then sintilimab and pemetrexed maintenance treatment for 2 years. In the squamous NSCLC, patients received sintilimab Injection (PD-1 inhibitor) 200mg, d1; liposome paclitaxel injection 135mg/m2, d1; carboplatin injection AUC 5, d1; CIK cells venous re-transfusion >=1x10^10, d14; Q3W, for 4 cycles. Then sintilimab maintenance treatment for 2 years. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03987867
Study type Interventional
Source Tianjin Medical University Cancer Institute and Hospital
Contact Xiubao Ren, MD. PhD.
Phone 86-22-23340123
Email liangcoh@163.com
Status Recruiting
Phase Phase 1
Start date June 1, 2019
Completion date June 1, 2021

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