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Clinical Trial Summary

Fibrous dysplasia of bone is a rare congenital but non-hereditary disease caused by a post-zygotic activation mutation of the GNAS gene. Patients with fibrous dysplasia may present pain and bone complications (fractures, deformities..) related to their bone lesions. For undetermined reasons, severity and disease evolution may vary considerably from patient to patient. Epigenetic regulation could then be involved, including micro Ribonucleic Acids (miRs). These small non-coding micro Ribonucleic Acids are involved in the regulation of major steps of cellular processes in different pathologies, in particular in bone diseases. However, micro Ribonucleic Acids have never been studied in fibrous dysplasia. The aim of this study is to identify micro Ribonucleic Acids significantly associated with the severity of fibrous dysplasia.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03838991
Study type Interventional
Source Hospices Civils de Lyon
Contact Roland CHAPURLAT, Pr
Phone 04 72 11 74 81
Email roland.chapurlat@chu-lyon.fr
Status Recruiting
Phase N/A
Start date January 10, 2019
Completion date February 10, 2025

See also
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Completed NCT00445575 - Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Phase 2/Phase 3
Completed NCT05422833 - Effectiveness of Medical Management of Fibrous Dysplasia of Bone.
Recruiting NCT06177327 - Hepato-pancreato-biliary Abnormalities in Fibrous Dysplasia of Bone/McCune Albright Syndrome
Active, not recruiting NCT05509595 - Burosumab for Fibroblast Growth Factor-23 Mediated Hypophosphatemia in Fibrous Dysplasia Phase 2