Chronic Liver Disease Clinical Trial
Official title:
Evaluation of Fibrosis and Steatosis in Patients With Chronic Hepatopathy: Non-invasive Imaging and Serum Markers vs. Liver Biopsy
The purpose of this study is to evaluate non-invasive parameters for staging and grading of chronic hepatopathy in comparison to liver biopsy.
For diagnosis, staging and grading of chronic liver disease, liver biopsy is the gold
standard to date. Unfortunately, being an invasive diagnostic method, liver biopsy has a
significant morbidity. Furthermore, due to the small sample size, sampling error (over- or
underestimating severity of liver disease) is a serious problem in diagnostic of chronic
liver disease.
The objective of this study is to evaluate non-invasive diagnostic methods (MRI,
elastography, ultrasound and serum parameters) in comparison to the gold standard to
establish criteria for diagnostic in liver disease and reduce the necessary amount of liver
biopsies in the future and allow regular follow up.
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Observational Model: Cohort, Time Perspective: Prospective
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